Autonomic circulatory control during pregnancy in humans.
Autonomic circulatory control during pregnancy in humans.
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DOI：
10.1055/s-0029-1225261
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发表时间：
2009-07
影响因子：
2.7
通讯作者：
Levine BD
中科院分区：
文献类型：
--
作者：
Fu Q;Levine BD
怀孕与母体血流动力学的剧烈变化有关，这种变化很早就开始（即受孕后，妊娠 4 至 5 周），并伴随着各种升压激素和血管活性代谢物水平的变化。有人提出这些变化是通过自主神经控制机制发生的，但自主神经系统在妊娠中的实际作用却知之甚少。新的研究进一步揭示了怀孕与心血管疾病之间的联系。因此，了解母体血流动力学自主控制的病理生理学对于预防怀孕期间的心血管并发症以及改善所有孕妇及以后生活的医疗护理非常有帮助且特别重要。在这篇综述中，我们重点介绍了一些先前的结果，包括妊娠期间的血流动力学适应和激素影响、与妊娠相关的血管内皮功能的变化、妊娠期间的交感神经控制和血管反应性以及人类妊娠期间的压力感受反射功能。然而，交感神经系统是否以及如何在人类妊娠早期的血流动力学稳态中发挥作用仍然完全未知。
Pregnancy is associated with dramatic alterations in maternal hemodynamics, which begin early (i.e., following conception, 4 to 5 weeks of gestation) and are accompanied by changing levels of various pressor hormones and vasoactive metabolites. It has been proposed that these changes occur through autonomic control mechanisms, but the actual role of the autonomic nervous system in pregnancy is poorly understood. New research has shed more light on the links between pregnancy and cardiovascular diseases. Thus, the understanding of the pathophysiology underlying autonomic control of maternal hemodynamics is extremely helpful and particularly important for prevention of cardiovascular complications during pregnancy, and for an improved medical care for all pregnant women and beyond into later life. In this review, we highlight some previous results of hemodynamic adaptation and hormonal effects during pregnancy, changes in vascular endothelial function associated with pregnancy, sympathetic neural control and vascular responsiveness in pregnancy, and baroreflex function during pregnancy in humans. However, whether and how the sympathetic nervous system plays a role in hemodynamic homeostasis during early human pregnancy remains completely unknown.
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影响因子：
19.6
作者：
Chapman, AB;Abraham, WT;Schrier, RW
通讯作者：
Schrier, RW
影响因子：
37.8
作者：
Fu, Q;Witkowski, S;Levine, BD
通讯作者：
Levine, BD
影响因子：
2.7
作者：
Faber, R;Baumert, M;Walther, T
通讯作者：
Walther, T
影响因子：
4.3
作者：
ENEROTHGRIMFORS, E;WESTGREN, M;LINDBLAD, LE
通讯作者：
LINDBLAD, LE
DOI：
10.1007/bf01826181
发表时间：
1994-08-01
期刊：
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
影响因子：
--
作者：
Ekholm, E M;Piha, S J;Antila, K J
通讯作者：
Antila, K J