Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study.
Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study.
复制标题
DOI：
10.1186/s12889-022-12569-3
复制
发表时间：
2022-01-27
影响因子：
4.5
通讯作者：
Moore JH
中科院分区：
文献类型：
--
作者：
Penrod NM;Moore JH
尽管进行了数十年的研究并制定了治疗策略，高血压仍然是人群中普遍存在且棘手的问题。瑜伽是一种基于生活方式的练习，已在临床试验中证明了其抗高血压作用，但对其在现实世界中的有效性知之甚少。在这里，我们使用电子健康记录来调查患者在日常生活中使用瑜伽的抗高血压作用。一项回顾性、观察性病例对照研究，对 2006 年至 2016 年间从地区学术卫生系统收集的 1355 名接触过瑜伽的患者中的 1815 份记录和 8682 名未接触过瑜伽的患者中的 40,326 份记录进行了研究。使用线性混合效应模型来估计瑜伽对收缩压和舒张压的平均治疗效果。使用混合效应逻辑回归模型来计算瑜伽使用和四种血压类别的比值比：正常、升高、I 期和 II 期高血压。瑜伽患者主要是白人（88.0%）和女性（87.8%），中位年龄为 46 岁（IQR 32-57），每周使用一次瑜伽（62.3%）。瑜伽与较低的收缩压（− 2.8 mmHg，标准误差 0.6；p < .001）和舒张压（− 1.5 mmHg，标准误差 0.5；p = 0.001）血压相关。相对于未接触瑜伽的患者，使用瑜伽的患者血压正常的几率增加了 85%（OR 1.85，95% CI 1.39–2.46）。 40-59 岁的患者患 II 期高血压的几率降低了 67%（0.33，95% CI 0.14-0.75）。所有效应大小均取决于年龄。患者在日常生活中使用的瑜伽可能是控制血压和预防人群高血压的有效策略。在线版本包含可在 10.1186/s12889-022-12569-3 获取的补充材料。
Despite decades of research and established treatment strategies, hypertension remains a prevalent and intractable problem at the population level. Yoga, a lifestyle-based practice, has demonstrated antihypertensive effects in clinical trial settings, but little is known about its effectiveness in the real world. Here, we use electronic health records to investigate the antihypertensive effects of yoga as used by patients in their daily lives. A retrospective, observational case-control study of 1815 records among 1355 yoga exposed patients and 40,326 records among 8682 yoga non-exposed patients collected between 2006 and 2016 from a regional academic health system. Linear mixed-effects models were used to estimate the average treatment effect of yoga on systolic and diastolic blood pressures. Mixed effects logistic regression models were used to calculate odds ratios for yoga use and four blood pressure categories: normal, elevated, stage I, and stage II hypertension. Yoga patients are predominantly white (88.0%) and female (87.8%) with median age 46 years (IQR 32–57) who use yoga one time per week (62.3%). Yoga is associated with lower systolic (− 2.8 mmHg, standard error 0.6; p < .001) and diastolic (− 1.5 mmHg, standard error 0.5; p = 0.001) blood pressures. Patients using yoga have 85% increased odds (OR 1.85, 95% CI 1.39–2.46) of having normal blood pressure relative to yoga non-exposed patients. Patients aged 40–59 years have 67% decreased odds (0.33, 95% CI 0.14–0.75) of having stage II hypertension. All effect sizes are age-dependent. Yoga, as used by patients in their daily lives, may be an effective strategy for blood pressure control and the prevention of hypertension at the population level. The online version contains supplementary material available at 10.1186/s12889-022-12569-3.
登录
查看更多内容
影响因子：
37.8
作者：
Muntner P;Carey RM;Gidding S;Jones DW;Taler SJ;Wright JT Jr;Whelton PK
通讯作者：
Whelton PK
DOI：
10.1056/nejmoa1605086
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Khera AV;Emdin CA;Drake I;Natarajan P;Bick AG;Cook NR;Chasman DI;Baber U;Mehran R;Rader DJ;Fuster V;Boerwinkle E;Melander O;Orho-Melander M;Ridker PM;Kathiresan S
通讯作者：
Kathiresan S
影响因子：
24
作者：
Chen, Vincent;Ning, Hongyan;Wilkins, John T.
通讯作者：
Wilkins, John T.
DOI：
10.3122/jabfm.2019.06.190115
发表时间：
2019-11-01
影响因子：
2.9
作者：
Penrod, Nadia M.;Lynch, Selah;Moore, Jason H.
通讯作者：
Moore, Jason H.
影响因子：
37.8
作者：
Pazoki, Raha;Dehghan, Abbas;Tzoulaki, Ioanna
通讯作者：
Tzoulaki, Ioanna