Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats.
Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats.
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DOI：
10.1016/j.physbeh.2011.05.026
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发表时间：
2011-11-30
影响因子：
2.9
通讯作者：
Woods, Stephen C.
中科院分区：
文献类型：
--
作者：
Chambers, Adam P.;Stefater, Margaret A.;Wilson-Perez, Hilary E.;Jessen, Lene;Sisley, Stephanie;Ryan, Karen K.;Gaitonde, Shrawan;Sorrell, Joyce E.;Toure, Mouhamadoul;Berger, Jose;D'Alessio, David A.;Sandoval, Darleen A.;Seeley, Randy J.;Woods, Stephen C.
关键词：
减肥手术是人类减肥最有效的手术，许多接受手术的患者除了体重减轻外，2 型糖尿病症状也显着减轻。我们将人类常用的两种减肥手术应用于大鼠模型，以开始了解能量稳态改善的机制。年轻成年雄性大鼠接受 roux-en-Y 胃旁路术 (RYGB) 或垂直袖状胃切除术 (VSG)，并在 28 周内评估体重、食物摄入量和葡萄糖稳态参数。对照大鼠要么接受假手术，要么不进行手术。相对于对照组，RYGB 和 VSG 具有相当的有益效果。他们吃的食物更少，体重减轻了更多，而且他们的血糖参数都得到了改善。研究结果最有趣的方面是，尽管胃肠系统的重新排列截然不同，但这两种手术却具有相似的效果。
Bariatric surgery is the most efficacious procedure for eliciting weight loss in humans, and many patients undergoing the procedure experience significant lessening of their symptoms of type-2 diabetes in addition to losing weight. We have adapted two bariatric surgical procedures commonly employed in humans to a rat model to begin to understand the mechanisms underlying the improvements in energy homeostasis. Young adult male rats received either roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) and were assessed for body weight, food intake and parameters of glucose homeostasis over a 28-week period. Control rats received either a sham surgical procedure or else were unoperated. RYGB and VSG had comparable beneficial effects relative to controls. They ate less food and lost more weight, and they both had improved glucose parameters. The most intriguing aspect of the findings is that the two surgical procedures had such similar effects in spite of quite different rearrangements of the gastrointestinal system.
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影响因子：
29.4
作者：
Stefater MA;Pérez-Tilve D;Chambers AP;Wilson-Pérez HE;Sandoval DA;Berger J;Toure M;Tschöp M;Woods SC;Seeley RJ
通讯作者：
Seeley RJ
影响因子：
4.9
作者：
James, W. P. T.
通讯作者：
James, W. P. T.
DOI：
10.1007/s00464-005-0134-5
发表时间：
2006-06-01
影响因子：
3.1
作者：
Cottam, D.;Qureshi, F. G.;Schauer, P.
通讯作者：
Schauer, P.
影响因子：
9
作者：
Karamanakos, Stavros N.;Vagenas, Konstantinos;Alexandrides, Theodore K.
通讯作者：
Alexandrides, Theodore K.
影响因子：
2.9
作者：
LAGACE, M;MARCEAU, P;BIRON, S
通讯作者：
BIRON, S