Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity.
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity.
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DOI：
10.1053/j.gastro.2010.02.059
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发表时间：
2010-06
期刊：
影响因子：
29.4
通讯作者：
Seeley RJ
中科院分区：
文献类型：
--
作者：
Stefater MA;Pérez-Tilve D;Chambers AP;Wilson-Pérez HE;Sandoval DA;Berger J;Toure M;Tschöp M;Woods SC;Seeley RJ
手术干预可使肥胖个体的体重持续减轻并改善代谢。垂直袖胃切除术（VSG）产生戏剧性的，持续的体重减轻；我们研究了这些变化是否源于对瘦素敏感性的提高。对饮食性肥胖的Long-Evans大鼠进行VSG实验。Naïve或假手术大鼠，自由喂养或与VSG组配对喂养，作为对照。手术后，监测体重和食物摄入量。我们研究了能量消耗、膳食模式、瘦素敏感性和大鼠下丘脑中促阿皮黑色素皮质素(POMC)/针刺相关肽(AgRP)/神经肽Y （NPY）的表达。我们观察到雄性和雌性大鼠在VSG后体重和体脂持续下降。术后短暂的食物摄入减少消失后，体重持续下降。静息能量消耗在对照组和VSG大鼠之间相似。VSG大鼠保持了减轻的体重。然而，他们对长期食物限制的反应是暴饮暴食，这导致了限制前的体重，而不是vsg前的体重。与低肥胖一致，VSG降低了血浆瘦素水平。尽管VSG略微改善了瘦素的厌食作用，但其反应与热量限制肥胖对照组的反应相当。下丘脑神经肽表达的变化与较低的体重和较低的瘦素水平一致，但不能解释持续的体重减轻。VSG导致体重持续减少，这是由于脂肪量的减少。所观察到的体重减轻的维持并不是由于对瘦素敏感性的改变。
Surgical intervention produces sustainable weight loss and metabolic improvement in obese individuals. Vertical sleeve gastrectomy (VSG) produces dramatic, sustained weight loss; we investigated whether these changes result from improved sensitivity to leptin. VSG was performed in Long-Evans rats with diet-induced obesity. Naïve or sham-operated rats, fed either ad libitum or pair-fed with the VSG group, were used as controls. Following surgery, body weights and food intake were monitored. We investigated energy expenditure, meal patterns, leptin sensitivity, and expression of pro-opiomelanocortin (POMC)/agouti-related peptide (AgRP)/neuropeptide Y (NPY) in the hypothalamus of the rats. We observed sustained losses in weight and body fat in male and female rats after VSG. Weight loss persisted after the disappearance of a transient, post-surgical food intake reduction. Resting energy expenditure was similar between control and VSG rats. VSG rats maintained their reduced body weights. However, they responded to a chronic food restriction challenge by overeating, which resulted in pre-restriction, rather than pre-VSG, body weights. Consistent with lower adiposity, VSG decreased plasma leptin levels. Although VSG slightly improved leptin’s anorectic action, the response was comparable to that observed in controls matched for adiposity by caloric restriction. Changes in hypothalamic neuropeptide expression were consistent with the lower body weight and lower leptin levels but cannot account for the sustained weight loss. VSG causes sustained reduction in body weight, which results from loss of fat mass. The maintenance of weight loss observed did not result from changes in sensitivity to leptin.
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影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG
DOI：
10.1007/s00464-005-0134-5
发表时间：
2006-06-01
影响因子：
3.1
作者：
Cottam, D.;Qureshi, F. G.;Schauer, P.
通讯作者：
Schauer, P.
影响因子：
9
作者：
Karamanakos, Stavros N.;Vagenas, Konstantinos;Alexandrides, Theodore K.
通讯作者：
Alexandrides, Theodore K.
影响因子：
158.5
作者：
Sjöström, L;Lindroos, AK;Wedel, H
通讯作者：
Wedel, H
影响因子：
4.8
作者：
McGregor, GP;Desaga, JF;Lang, RE
通讯作者：
Lang, RE