Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior.
Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior.
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父亲和母亲的孕前和母亲怀孕尿邻苯二甲酸酯代谢物和 BPA 浓度与儿童行为的关系。
DOI：
10.1016/j.envint.2023.108337
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发表时间：
2024
影响因子：
11.8
通讯作者：
Braun,JosephM
中科院分区：
文献类型：
--
作者：
Leader,Jordana;Mínguez-Alarcón,Lidia;Williams,PaigeL;Ford,JenniferB;Dadd,Ramace;Chagnon,Olivia;Bellinger,DavidC;Oken,Emily;Calafat,AntoniaM;Hauser,Russ;Braun,JosephM
背景关于父母孕前暴露对健康影响的流行病学研究是有限的，尽管毒理学研究的新证据表明，这种暴露，包括环境化学品，我们调查了母亲和父亲的孕前和母亲怀孕尿邻苯二甲酸酯代谢物和双酚A（BPA）浓度与儿童行为有关。方法我们分析了来自孕前环境暴露和儿童健康影响（PEACE）研究的数据，一项正在进行的前瞻性队列研究，研究对象为6-11岁的儿童，其父母曾参加过前瞻性孕前环境与生殖健康（EARTH）研究。使用线性混合模型，我们估计了11种邻苯二甲酸酯代谢物和BPA浓度的协变量调整后的关联，这些浓度是在怀孕前和怀孕期间收集的，与儿童行为评估系统-3（BASC-3）T评分有关结果本次分析包括134名母亲、87名父亲和157名儿童（24对双胞胎）;父母主要是非西班牙裔白色（母亲和父亲86%）。较高的母亲孕前或妊娠邻苯二甲酸单苄酯（MBzP）浓度与其子女较高的平均外化问题T评分相关（β = 1.3/1 logeunit增加; 95% CI：-0.2，2.4和β = 2.1，95% CI：0.7，3.6）。较高的母体孕前邻苯二甲酸单羧基辛酯（MCOP）与较低的平均外化问题T评分相关（β = -0.9; 95%CI：-1.8，0.0）。较高的父亲孕前MCOP与较低的内化问题相关（β = -0.9，95%CI：-1.9，0.1）和行为症状指数（BSI）T评分较低（β = -1.3; 95% CI：结论在该队列中，较高的母亲孕前和妊娠MBzP与父母报告的儿童行为较差相关，而母亲和父亲孕前MCOP浓度较高与BASC-3评分较低有关。
BackgroundEpidemiologic studies on health effects of parental preconception exposures are limited despite emerging evidence from toxicological studies suggesting that such exposures, including to environmental chemicals, may affect offspring health.ObjectiveWe investigated whether maternal and paternal preconception and maternal pregnancy urinary phthalate metabolite and bisphenol A (BPA) concentrations were associated with child behavior.MethodsWe analyzed data from the Preconception Environmental exposure And Childhood health Effects (PEACE) Study, an ongoing prospective cohort study of children aged 6–11 years whose parent(s) previously enrolled in the prospective preconception Environment and Reproductive Health (EARTH) study. Using linear mixed models, we estimated covariate-adjusted associations of 11 urinary phthalate metabolite and BPA concentrations collected prior to conception and during pregnancy with Behavioral Assessment System for Children-3 (BASC-3) T-scores (higher scores indicate more problem behaviors).ResultsThis analysis included 134 mothers, 87 fathers and 157 children (24 sets of twins); parents were predominantly non-Hispanic white (mothers and fathers86%). Higher maternal preconception or pregnancy monobenzyl phthalate (MBzP) concentrations were related to higher mean externalizing problems T-scores in their children (β = 1.3 per 1-logeunit increase; 95 % CI: −0.2, 2.4 and β = 2.1, 95 % CI: 0.7, 3.6, respectively). Higher maternal preconception monocarboxyoctyl phthalate (MCOP) was suggested to be related to lower mean externalizing problems T-scores (β = -0.9; 95 % CI: −1.8, 0.0). Higher paternal preconception MCOP was suggestively associated with lower internalizing problems (β = -0.9; 95 %CI:-1.9, 0.1) and lower Behavioral Symptoms Index (BSI) T-scores (β = -1.3; 95 % CI: −2.1, −0.4).ConclusionIn this cohort, higher maternal preconception and pregnancy MBzP were associated with worse parent-reported child behavior, while higher maternal and paternal preconception MCOP concentrations were related to lower BASC-3 scores.
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DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
D. Symons
通讯作者：
D. Symons
性腺切除恒河猴的行为 I. PLAY1
DOI：
--
发表时间：
1978
期刊：
影响因子：
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作者：
J. Loy;K. Loy;D. Patterson;G. Keifer;C. Conaway
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C. Conaway
影响因子：
2.9
作者：
Ferguson,SA;Bowman,RE
通讯作者：
Bowman,RE
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影响因子：
22.4
作者：
S. Maxwell;R. Arvey
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R. Arvey
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DOI：
--
发表时间：
1979
期刊：
影响因子：
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作者：
Bushnell Pj;Bowman Re
通讯作者：
Bowman Re