Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.
Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.
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DOI：
10.1038/s41467-023-42205-6
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发表时间：
2023-11-15
影响因子：
16.6
通讯作者：
Baillie, J. Kenneth
中科院分区：
文献类型：
--
作者：
Swets, Maaike C.;Kerr, Steven;Scott-Brown, James;Brown, Adam B.;Gupta, Rishi;Millar, Jonathan E.;Spata, Enti;Mccurrach, Fiona;Bretherick, Andrew D.;Docherty, Annemarie;Harrison, David;Rowan, Kathy;Young, Neil;Groeneveld, Geert H.;Dunning, Jake;Nguyen-Van-Tam, Jonathan S.;Openshaw, Peter;Horby, Peter W.;Harrison, Ewen;Staplin, Natalie;Semple, Malcolm G.;Lone, Nazir;Baillie, J. Kenneth
选择最佳的结局指标可以最大限度地提高统计功效，加速发现并提高早期试验的可靠性。我们设计并评估了一种实用的氧合功能测量方法，即比率的修改。由于氧合血红蛋白饱和度的天花板效应，比值在高值时不再反映肺氧合功能。我们发现，当排除并将该测量值称为时，与参比标准品（/比值）的相关性大幅改善。使用来自39，765名住院COVID-19患者的观察数据，我们证明了这是死亡率的预测，并使用四种不同的结局指标比较了试验所需的样本量。我们表明，一个显着的差异，结果可以检测到最小的样本量使用。我们证明这是COVID-19中有效的中间结果指标。它是一种非侵入性测量，代表疾病的严重程度，并提供更大的统计功效。需要一种肺氧合功能的准确测量方法，可用作实用临床试验的中间终点，以提高统计功效和效率。在这里，作者表明，S/F 94，S/F比的修改，是一个简单，有意义和有效的中间结果的措施。
Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the ratio. Because of the ceiling effect in oxyhaemoglobin saturation, ratio ceases to reflect pulmonary oxygenation function at high values. We found that the correlation of with the reference standard (/ ratio) improves substantially when excluding and refer to this measure as . Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using . We demonstrate that is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power. There is a need for an accurate measure of pulmonary oxygenation function that can be used as an intermediate endpoint in pragmatic clinical trials, to increase statistical power and efficiency. Here, the authors show that the S/F94, a modification of the S/F ratio, is a simple, meaningful and effective intermediate outcome measure.
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影响因子：
--
作者：
Carvalho, Eduardo Butturini de;Leite, Thiago Ravache Sobreira;Sacramento, Raquel Ferreira de Magalhaes;Nascimento, Paulo Roberto Loureiro do;Samary, Cynthia Dos Santos;Rocco, Patricia Rieken Macedo;Silva, Pedro Leme
通讯作者：
Silva, Pedro Leme
影响因子：
8.8
作者：
Brown, Samuel M.;Duggal, Abhijit;Brower, Roy G.
通讯作者：
Brower, Roy G.
DOI：
10.1016/s0140-6736(20)32008-0
发表时间：
2020-10-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Barbaro RP;MacLaren G;Boonstra PS;Iwashyna TJ;Slutsky AS;Fan E;Bartlett RH;Tonna JE;Hyslop R;Fanning JJ;Rycus PT;Hyer SJ;Anders MM;Agerstrand CL;Hryniewicz K;Diaz R;Lorusso R;Combes A;Brodie D;Extracorporeal Life Support Organization
通讯作者：
Extracorporeal Life Support Organization
DOI：
10.1016/s0140-6736(22)01109-6
发表时间：
2022-07-30
期刊：
Lancet (London, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.6
作者：
Brown, Samuel M.;Grissom, Colin K.;Brower, Roy G.
通讯作者：
Brower, Roy G.