Endothelial dysfunction and subclinical atherosclerosis as evidenced by the measurement of flow mediated dilatation of brachial artery and carotid intima media thickness in patients with rheumatoid arthritis
Endothelial dysfunction and subclinical atherosclerosis as evidenced by the measurement of flow mediated dilatation of brachial artery and carotid intima media thickness in patients with rheumatoid arthritis
复制标题
类风湿性关节炎患者的肱动脉血流介导扩张和颈动脉内膜中层厚度的测量证实内皮功能障碍和亚临床动脉粥样硬化
DOI：
10.1016/j.ejrnm.2012.12.009
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hytham Haroon Elsaid
中科院分区：
文献类型：
--
作者：
Noha Mohamed AbdelMaboud;Hytham Haroon Elsaid
工作目的本研究旨在通过评估类风湿性关节炎患者肱动脉血流介导的扩张，评估颈动脉内膜中层厚度和内皮依赖性功能，评估亚临床动脉粥样硬化和心血管疾病的患病率。材料和方法26名类风湿性关节炎患者和20名健康对照受试者使用B-测量肱动脉FMD和CIMT结果类风湿性关节炎组肱动脉FMD为-96.6-6.6%，提示艾德，对照组为20-25%。CIMT为0.50-0.72 mm，类风湿关节炎和0.35-0.47 mm，在control group.ConclusionThe结果从本研究支持使用颈动脉US和内皮功能评估通过FMD作为一个有用的工具来预测类风湿关节炎患者心血管疾病的风险增加。我们建议所有类风湿关节炎患者都应进行颈动脉超声检查，以确定需要更积极治疗的心血管并发症的风险。
Aim of the workThe present study aimed at evaluating the prevalence of subclinical atherosclerosis and cardiovascular disease by means of assessment of carotid intima media thickness and endothelium dependent function through assessment of brachial artery flow mediated dilatation in patients with rheumatoid arthritis.Materials and methodsTwenty six patients with rheumatoid arthritis and 20 healthy control subjects underwent measurement of brachial artery FMD and CIMT using B-mode gray scale US for evaluating cardiovascular risk.ResultsThe brachial artery FMD was –96.6–6.6% in rheumatoid arthritis (indicating ED), and 20–25% in the control group. The CIMT was 0.50–0.72 mm in rheumatoid arthritis and 0.35–0.47 mm in the control group.ConclusionThe results from the present study support the use of carotid US and endothelial function assessment by means of FMD as a useful tool to predict the increased risk of cardiovascular disease in patients with rheumatoid arthritis. We suggest that the carotid artery US should be performed for all patients with rheumatoid arthritis to establish the risk of cardiovascular complication which requires more aggressive therapy.
影响因子：
158.5
作者：
O'Leary, DH;Polak, JF;Wolfson, SK
通讯作者：
Wolfson, SK