Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.
复制标题
DOI：
10.3390/metabo12080735
复制
发表时间：
2022-08-09
期刊：
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
吸烟是可预防死亡的主要原因。许多报告将怀孕期间吸烟与严重的不良后果联系起来，例如流产、死产、早产、低出生体重、围产期发病率和婴儿死亡率。与吸烟无关，在怀孕期间摄入尼古丁的推论较少被探索，而且尼古丁对母婴交流的作用机制也知之甚少。这项研究检查了母体肠道微生物群因怀孕期间接触尼古丁而发生的变化。我们报告说，母体肠道微生物群环境的变化是一个重要的中介因素，可能介导产前尼古丁暴露效应，影响基因表达，并改变胎儿在子宫发育过程中对循环短链脂肪酸（SCFA）和瘦素的暴露。
Tobacco smoking is the leading cause of preventable death. Numerous reports link smoking in pregnancy with serious adverse outcomes, such as miscarriage, stillbirth, prematurity, low birth weight, perinatal morbidity, and infant mortality. Corollaries of consuming nicotine in pregnancy, separate from smoking, are less explored, and the mechanisms of nicotine action on maternal–fetal communication are poorly understood. This study examined alterations in the maternal gut microbiome in response to nicotine exposure during pregnancy. We report that changes in the maternal gut microbiota milieu are an important intermediary that may mediate the prenatal nicotine exposure effects, affect gene expression, and alter fetal exposure to circulating short-chain fatty acids (SCFAs) and leptin during in utero development.
登录
查看更多内容
影响因子：
7.4
作者：
Banderali G;Martelli A;Landi M;Moretti F;Betti F;Radaelli G;Lassandro C;Verduci E
通讯作者：
Verduci E
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
5.3
作者：
Chang, Guo-Qing;Karatayev, Olga;Leibowitz, Sarah F.
通讯作者：
Leibowitz, Sarah F.
影响因子：
5.5
作者：
Coan, P. M.;Vaughan, O. R.;Fowden, A. L.
通讯作者：
Fowden, A. L.
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J