Adherence of Streptococcus pneumoniae to immobilized fibronectin
Adherence of Streptococcus pneumoniae to immobilized fibronectin
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肺炎链球菌对固定化纤连蛋白的粘附
DOI：
--
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发表时间：
1995
影响因子：
3.1
通讯作者：
Andelaine I. Tuomanen
中科院分区：
文献类型：
--
作者：
Michiel Van Derflier;Nok Chhun;Theresa M. Wizemann;Jenny Min;James B. McCarthy;Andelaine I. Tuomanen
粘附于细胞外基质蛋白，如纤连蛋白，为病原体提供了侵入受损上皮的机制。发现肺炎链球菌比其他链球菌和葡萄球菌更贪婪地粘附于固定化纤维连接蛋白。结合具有剂量、时间和温度依赖性。胰蛋白酶处理的细菌导致结合减少，表明细菌的粘附成分是一种蛋白质。通过蛋白水解或重组基因片段的表达产生的纤连蛋白的片段进行了比较的能力，结合肺炎球菌和竞争细菌结合固定化纤连蛋白。从羧基末端肝素结合域的片段是一贯活跃的，这表明该地区含有肺炎球菌的结合位点，一个区域不同的支持大多数其他细菌的附着。
Adherence to extracellular matrix proteins, such as fibronectin, affords pathogens with a mechanism to invade injured epithelia. Streptococcus pneumoniae was found to adhere to immobilized fibronectin more avidly than other streptococci and staphylococci do. Binding was dose, time, and temperature dependent. Trypsin treatment of the bacteria resulted in decreased binding, suggesting that the bacterial adhesive component was a protein. Fragments of fibronectin generated by proteolysis or by expression of recombinant gene segments were compared for the ability to bind pneumococci and to compete against bacterial binding to immobilized fibronectin. Fragments from the carboxy-terminal heparin binding domain were consistently active, suggesting that this region contains the pneumococcal binding site, a region distinct from that supporting the attachment of most other bacteria.
肺炎球菌心内膜炎：系列报告和文献综述。
DOI：
10.1093/clinids/8.5.786
发表时间：
1986
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Powderly,WG;StanleyJr,SL;Medoff,G
通讯作者：
Medoff,G
纤连蛋白与链球菌的相互作用：纤连蛋白作为化脓性链球菌受体的作用。
DOI：
10.1093/clinids/9.supplement_4.s351
发表时间：
1987
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Simpson,WA;Courtney,HS;Ofek,I
通讯作者：
Ofek,I
影响因子：
6.4
作者：
TUOMANEN, E;LIU, H;TOMASZ, A
通讯作者：
TOMASZ, A