Platelet-to-lymphocyte percentage ratio index: a simple non-invasive index to monitor the endoscopic activity in Crohn's disease.
Platelet-to-lymphocyte percentage ratio index: a simple non-invasive index to monitor the endoscopic activity in Crohn's disease.
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血小板与淋巴细胞百分比比指数：一种简单的非侵入性指数，用于监测克罗恩病的内镜活动。
DOI：
10.1177/1756284820979442
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发表时间：
2020
影响因子：
4.2
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Chen R;Li L;Chao K;Hong M;Cao Q;Ye L;Zhou G;Fang X;Guo H;Cao X;Ye X;Zeng Z;Chen M;Zhang S
最近的证据表明克罗恩病（CD）患者的全血细胞计数（CBC）异常。我们的目的是研究有效的 CBC 参数，并探讨其对大型 CD 队列中疾病活动的影响。我们对 2016 年至 2020 年间在中国四个三级中心接受临床指征内镜检查的确诊 CD 患者进行了回顾性分析。CD 简单内镜评分、CBC 参数、C 反应蛋白 (CRP) 水平、红细胞沉降率和粪便钙卫蛋白 (FC) 的各个变量由不同研究人员独立审查。采用保留法验证所建立模型的预测能力。共对 882 名符合条件的 CD 患者进行了 1388 次内窥镜手术，数据包括常规血液参数和相关指标。使用血小板与淋巴细胞百分比比（PLpR）的模型对于识别内镜缓解（ER）患者具有较高的准确性，曲线下面积（AUC）为0.785 [95%置信区间（CI）：0.784–0.787]，与CRP模型（AUC：0.775，95% CI：0.774–0.777）相当。值得注意的是，在患有结肠疾病且有手术史的患者中，PLpR 的 AUC 显着高于 CRP。此外，将FC与PLpR结合后，FC + PLpR用于识别ER的AUC值增加至0.892（95％CI：0.890-0.894）。我们探索了一个指数 (PLpR)，用于根据 CBC 中的血小板和淋巴细胞百分比来识别 ER 中的 CD 患者。 PLpR 有助于评估疾病活动程度并监测治疗反应。
Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn’s disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on disease activity in a large CD cohort. We performed a retrospective analysis of patients with established CD who underwent clinically indicated endoscopy at four tertiary centres in China between 2016 and 2020. Individual variables of the Simple Endoscopic Score for CD, CBC parameters, C-reactive protein (CRP) levels, erythrocyte sedimentation rate, and faecal calprotectin (FC) were independently reviewed by different investigators. The hold-out method was used to verify the predictive power of the established model. Data from a total of 1388 endoscopic procedures performed for 882 eligible CD patients were available with routine blood parameters and related indicators. The model using platelet-to-lymphocyte percentage ratio (PLpR) had high accuracy for identifying patients in endoscopic remission (ER), with an area under the curve (AUC) of 0.785 [95% confidence interval (CI): 0.784–0.787], which was comparable with that for CRP (AUC: 0.775, 95% CI: 0.774–0.777). Notably, the AUC of PLpR was significantly higher than that of CRP in patients with colonic disease and with a history of surgery. Moreover, after combining the FC with PLpR, the AUC value of FC + PLpR increased up to 0.892 (95% CI: 0.890–0.894) for identifying ER. We explored an index (PLpR) to identify CD patients in ER based on platelet and lymphocyte percentage from the CBC. PLpR helped evaluate the degree of disease activity and monitor the therapeutic response.
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影响因子：
4.3
作者：
Goyal H;Lippi G;Gjymishka A;John B;Chhabra R;May E
通讯作者：
May E
影响因子：
4.9
作者：
Buisson, Anthony;Gonzalez, Florent;Bouguen, Guillaume
通讯作者：
Bouguen, Guillaume
影响因子：
4.9
作者：
Bertani, Lorenzo;Rossari, Federico;Costa, Francesco
通讯作者：
Costa, Francesco
影响因子：
8
作者：
Goutorbe, F.;Goutte, M.;Buisson, A.
通讯作者：
Buisson, A.
影响因子：
4.9
作者：
Kawashima, Kousaku;Ishihara, Shunji;Kinoshita, Yoshikazu
通讯作者：
Kinoshita, Yoshikazu