Prognostic significance of red blood cell distribution width in gastrointestinal disorders.
Prognostic significance of red blood cell distribution width in gastrointestinal disorders.
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DOI：
10.3748/wjg.v23.i27.4879
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发表时间：
2017-07-21
影响因子：
4.3
通讯作者：
May E
中科院分区：
文献类型：
--
作者：
Goyal H;Lippi G;Gjymishka A;John B;Chhabra R;May E
红细胞分布宽度（RDW）是一项常规测量和自动报告的血液参数，它反映了红细胞异数的程度。最近，基线RDW被发现对评估包括心血管疾病、败血症、癌症、白血病、肾功能障碍和呼吸系统疾病在内的各种病理状况的临床结局和严重程度具有临床意义。无数的因素，其中大多数是不明确的，有影响红细胞种群动态（即，生产，成熟和周转）。在病理条件下，红细胞清除的延迟是细胞异数增多的主要决定因素之一。进一步研究RDW可能会揭示炎症机制的新见解。在这篇综述中，我们专门讨论了目前关于RDW在胃肠道和肝胆系统的各种疾病中的关联的文献。我们还提出了一些相关的测量值，用于预测这种情况下的临床结果。根据我们的数据，我们发现RDW与其他炎症生物标志物（即C反应蛋白、红细胞沉降率和血小板计数）和临床实践中使用的当前疾病严重程度指标一起是胃肠道疾病的有价值的预后指标。
The red blood cell distribution width (RDW) is a routinely measured and automatically reported blood parameter, which reflects the degree of anisocytosis. Recently, the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases, sepsis, cancers, leukemia, renal dysfunction and respiratory diseases. A myriad of factors, most of which ill-defined, have an impact on the red cell population dynamics (i.e., production, maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review, we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data, RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers (i.e., C reactive protein, erythrocyte sedimentation rate, and platelet count) and current disease severity indices used in clinical practice.
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DOI：
10.1097/00042737-200202000-00012
发表时间：
2002-02-01
影响因子：
2.1
作者：
Guidetti, CS;Scaglione, N;Martini, S
通讯作者：
Martini, S
影响因子：
--
作者：
Beyazit, Yavuz;Kekilli, Murat;Arhan, Mehmet
通讯作者：
Arhan, Mehmet
影响因子：
2.1
作者：
Gulen, Bedia;Sonmez, Ertan;Sogut, Ozgur
通讯作者：
Sogut, Ozgur
影响因子：
1.6
作者：
Balaban, Daniel Vasile;Popp, Alina;Jinga, Mariana
通讯作者：
Jinga, Mariana
影响因子：
1.2
作者：
Bilgic, I.;Dolu, F.;Tez, M.
通讯作者：
Tez, M.