Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study.
Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study.
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DOI：
10.3389/fendo.2021.706369
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发表时间：
2021
影响因子：
5.2
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Mao Y;Zhang C;Wang Y;Meng Y;Chen L;Dennis CL;Sheng J;Wu Y;Huang H
虽然根据健康和疾病的发育起源理论（DOHaD），有充分的证据表明，母亲的不良接触会导致后代健康的一系列缺陷，但父亲的证据仍然不足。父亲年龄偏大与多种代谢和精神疾病有关。出生体重是评价胎儿生长发育最直接的指标。因此，我们设计了这项研究来探讨足月和早产（<37周妊娠）婴儿的父亲年龄和出生体重之间的关系。研究人员利用2015年1月至2019年12月的基于人群的医院数据进行了一项大型回顾性研究，其中包括69964例具有完整父亲年龄数据的单胎婴儿。主要结局是按性别和胎龄分层的婴儿出生体重，包括胎龄小（SGA，第10百分位）和胎龄大（LGA，第90百分位）。按胎龄划分的出生体重百分位数基于intergrowth -21新生儿胎龄体重标准中公布的数据。采用Logistic回归分析和线性回归模型估计父亲年龄与婴儿出生体重的关系。父亲年龄较大与早产风险较高相关[35-44岁：校正优势比(OR) = 1.13, 95%CI (1.03 ~ 1.24)；[44岁：OR = 1.36, 95%CI(1.09 ~ 1.70)]。父亲年龄对出生体重产生相反的影响，早产婴儿（35 - 44岁：OR = 1.85, 95%CI(1.18 ~ 2.89)）发生SGA的风险增加，足月婴儿（35 - 44岁：OR = 0.81, 95%CI(0.68 ~ 0.98)）发生SGA的风险降低；44岁：OR = 0.50, 95%CI（0.26 ~ 0.94）。与分娩时年龄在25岁至34岁之间的父亲相比，足月婴儿的LGA风险在年轻父亲（<25岁）（OR = 1.32; 95%CI， 1.07至1.62）和年长父亲（35-44岁）（OR = 1.07; 95%CI， 1.01至1.14）中均较高。我们的研究发现，父亲年龄的增加增加了早产儿SGA和足月婴儿LGA的风险。这些发现可能反映了病理生理学病因，具有重要的孕前护理意义，并建议需要进行产前监测。
While it is well documented that maternal adverse exposures contribute to a series defects on offspring health according to the Developmental Origins of Health and Disease (DOHaD) theory, paternal evidence is still insufficient. Advanced paternal age is associated with multiple metabolism and psychiatric disorders. Birth weight is the most direct marker to evaluate fetal growth. Therefore, we designed this study to explore the association between paternal age and birth weight among infants born at term and preterm (<37 weeks gestation). A large retrospective study was conducted using population-based hospital data from January 2015 to December 2019 that included 69,964 cases of singleton infant births with complete paternal age data. The primary outcome was infant birth weight stratified by sex and gestational age including small for gestational age (SGA, 10th percentile) and large for gestational age (LGA, 90th percentile). Birth weight percentiles by gestational age were based on those published in the INTERGROWTH-21st neonatal weight-for gestational-age standard. Logistic regression analysis and linear regression model were used to estimate the association between paternal age and infant birth weight. Advanced paternal age was associated with a higher risk for a preterm birth [35–44 years: adjusted odds ratio (OR) = 1.13, 95%CI (1.03 to 1.24); >44 years: OR = 1.36, 95%CI (1.09 to 1.70)]. Paternal age exerted an opposite effect on birth weight with an increased risk of SGA among preterm infants (35–44years: OR = 1.85, 95%CI (1.18 to 2.89) and a decreased risk among term infant (35–44years: OR = 0.81, 95%CI (0.68 to 0.98); >44 years: OR = 0.50, 95%CI (0.26 to 0.94). U-shaped associations were found in that LGA risk among term infants was higher in both younger (<25 years) (OR = 1.32; 95%CI, 1.07 to 1.62) and older (35–44 years) (OR = 1.07; 95% CI, 1.01 to 1.14) fathers in comparison to those who were 25 to 34 years old at the time of delivery. Our study found advanced paternal age increased the risk of SGA among preterm infants and for LGA among term infants. These findings likely reflect a pathophysiology etiology and have important preconception care implications and suggest the need for antenatal monitoring.
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DOI：
10.1136/bmj.b2393
发表时间：
2009-06-29
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