Endoplasmic Reticulum Stress in Metabolic Disorders.
Endoplasmic Reticulum Stress in Metabolic Disorders.
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DOI：
10.3390/cells7060063
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发表时间：
2018-06-19
期刊：
影响因子：
6
通讯作者：
Arnold C
中科院分区：
文献类型：
--
作者：
Ghemrawi R;Battaglia-Hsu SF;Arnold C
代谢紊乱已成为对人类健康最严重的威胁之一，导致严重的慢性疾病，如肥胖、2型糖尿病和非酒精性脂肪肝以及心血管疾病。有趣的是，尽管这些疾病中的每一种都具有不同的生理和临床症状，但它们似乎具有某些共同的病理特征，例如由代谢紊乱引起的细胞内应激和炎症，这些代谢紊乱源于经常由现代久坐不动的生活方式加剧的营养过剩。这些现代生活方式使细胞和器官淹没在饱和水平的糖和脂肪中，导致糖毒性和脂毒性，其诱导细胞内应激信号传导，从氧化到ER应激反应，以科普代谢损伤（Mukherjee，et al.，2015）。在这篇综述中，我们讨论了细胞应激及其反应在形成代谢紊乱中所起的作用。我们在这里总结了目前的机制的见解，解释这些疾病的发病机制。随后讨论了针对应激反应途径的最新疗法。
Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style. These modern ways of living inundate cells and organs with saturating levels of sugar and fat, leading to glycotoxicity and lipotoxicity that induce intracellular stress signaling ranging from oxidative to ER stress response to cope with the metabolic insults (Mukherjee, et al., 2015). In this review, we discuss the roles played by cellular stress and its responses in shaping metabolic disorders. We have summarized here current mechanistic insights explaining the pathogenesis of these disorders. These are followed by a discussion of the latest therapies targeting the stress response pathways.
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