Metabolic Syndrome and Breast Cancer: Prevalence, Treatment Response, and Prognosis.
Metabolic Syndrome and Breast Cancer: Prevalence, Treatment Response, and Prognosis.
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代谢综合征和乳腺癌：患病率、治疗反应和预后
DOI：
10.3389/fonc.2021.629666
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Dong S;Wang Z;Shen K;Chen X
代谢综合征是一种多因素代谢性疾病，至少存在三个因素：肥胖、糖尿病、低高密度脂蛋白、高甘油三酯血症和高血压。近年来的研究表明，代谢综合征及其相关成分对乳腺癌的发生、发展、治疗反应和预后有重要影响。代谢异常不仅会增加疾病风险，加剧肿瘤进展，而且会导致不良的治疗反应和更多的治疗副作用。此外，这些代谢成分失衡引起的生化反应会影响宿主总体状态和器官特异性肿瘤微环境，导致复发率和死亡率增加。因此，本文就代谢综合征与乳腺癌相关性的最新研究进展进行综述，以期为改善乳腺癌预后提供潜在的新治疗靶点和干预策略。
Metabolic syndrome is a type of multifactorial metabolic disease with the presence of at least three factors: obesity, diabetes mellitus, low high-density lipoprotein, hypertriglyceridemia, and hypertension. Recent studies have shown that metabolic syndrome and its related components exert a significant impact on the initiation, progression, treatment response, and prognosis of breast cancer. Metabolic abnormalities not only increase the disease risk and aggravate tumor progression but also lead to unfavorable treatment responses and more treatment side effects. Moreover, biochemical reactions caused by the imbalance of these metabolic components affect both the host general state and organ-specific tumor microenvironment, resulting in increased rates of recurrence and mortality. Therefore, this review discusses the recent advances in the association of metabolic syndrome and breast cancer, providing potential novel therapeutic targets and intervention strategies to improve breast cancer outcome.
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