Crossroads of Drug Abuse and HIV Infection: Neurotoxicity and CNS Reservoir.
Crossroads of Drug Abuse and HIV Infection: Neurotoxicity and CNS Reservoir.
复制标题
DOI：
10.3390/vaccines10020202
复制
发表时间：
2022-01-27
期刊：
影响因子：
7.8
通讯作者：
Tyagi M
中科院分区：
文献类型：
--
作者：
Sonti S;Tyagi K;Pande A;Daniel R;Sharma AL;Tyagi M
药物滥用是艾滋病毒感染者的常见并发症。吸毒的艾滋病毒感染者是艾滋病毒连续护理沿着经常经历次优结果的关键人群。一小部分艾滋病毒感染者会出现与艾滋病毒相关的神经认知问题，其严重程度随着药物滥用而进一步增加。此外，病毒在某些细胞库中潜伏的趋势再次使消除艾滋病毒和艾滋病毒相关疾病的工作复杂化。抗逆转录病毒疗法（ART）成功地降低了感染者的总体病毒载量，但它不能有效地消除所有潜伏宿主中的病毒。虽然ART增加了受感染个体的预期寿命，但它在CNS功能方面表现出不一致的改善，从而降低了生活质量。研究工作一直致力于确定艾滋病毒和药物滥用导致神经毒性和中枢神经系统功能障碍的共同机制。因此，为了开发一种有效的治疗方案来治疗HIV感染患者的神经认知和相关症状，了解神经毒性的相关机制至关重要。最终，这些机制可以引导设计和开发新的治疗策略，解决CNS HIV储库和HIV患者的非法药物使用。
Drug abuse is a common comorbidity in people infected with HIV. HIV-infected individuals who abuse drugs are a key population who frequently experience suboptimal outcomes along the HIV continuum of care. A modest proportion of HIV-infected individuals develop HIV-associated neurocognitive issues, the severity of which further increases with drug abuse. Moreover, the tendency of the virus to go into latency in certain cellular reservoirs again complicates the elimination of HIV and HIV-associated illnesses. Antiretroviral therapy (ART) successfully decreased the overall viral load in infected people, yet it does not effectively eliminate the virus from all latent reservoirs. Although ART increased the life expectancy of infected individuals, it showed inconsistent improvement in CNS functioning, thus decreasing the quality of life. Research efforts have been dedicated to identifying common mechanisms through which HIV and drug abuse lead to neurotoxicity and CNS dysfunction. Therefore, in order to develop an effective treatment regimen to treat neurocognitive and related symptoms in HIV-infected patients, it is crucial to understand the involved mechanisms of neurotoxicity. Eventually, those mechanisms could lead the way to design and develop novel therapeutic strategies addressing both CNS HIV reservoir and illicit drug use by HIV patients.
登录
查看更多内容
DOI：
10.1164/ajrccm.156.5.9704146
发表时间：
1997-11-01
影响因子：
24.7
作者：
Baldwin, GC;Tashkin, DP;Roth, MD
通讯作者：
Roth, MD
DOI：
10.1006/bbrc.1998.8321
发表时间：
1998-03-27
影响因子：
3.1
作者：
Bagetta, G;Corasaniti, MT;Finazzi-Agrò, A
通讯作者：
Finazzi-Agrò, A
影响因子：
7.3
作者：
Avraham, Hava Karsenty;Jiang, Shuxian;Avraham, Shalom
通讯作者：
Avraham, Shalom
影响因子：
6.7
作者：
Alvarez-Carbonell, David;Ye, Fengchun;Karn, Jonathan
通讯作者：
Karn, Jonathan
影响因子：
5.2
作者：
Blas-Garcia, Ana;Polo, Miriam;Esplugues, Juan V.
通讯作者：
Esplugues, Juan V.