Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids.
Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids.
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DOI：
10.1016/j.bbalip.2022.159139
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Voelker DR
中科院分区：
文献类型：
--
作者：
Numata M;Voelker DR
肺表面活性物质是脂质和蛋白质的混合物，由90%重量的磷脂和10%重量的蛋白质组成，主要存在于脊椎动物肺的肺泡中。肺表面活性剂磷脂的两种次要组分磷脂酰甘油（PG）和磷脂酰肌醇（PI）以非常高的浓度存在于肺泡内，并且通过拮抗同源配体依赖性活化来调节多种Toll样受体（TLR 2/1、TLR 4和TLR 2/6）而发挥抗炎作用。POPG还在体内减弱LPS诱导的肺损伤。此外，这些脂质直接与RSV和甲型流感病毒（IAV）结合，并阻断宿主细胞和病毒体之间的相互作用，从而防止病毒在体外复制。POPG和PI还在小鼠和雪貂体内抑制RSV和IAV感染。脂质体在体外对SARS-CoV-2感染有明显的抑制作用。这些研究结果表明，POPG和PI都有很强的潜力，可用于预防和感染后治疗有问题的呼吸道病毒感染。
Pulmonary surfactant is a mixture of lipids and proteins, consisting of 90% phospholipid, and 10% protein by weight, found predominantly in pulmonary alveoli of vertebrate lungs. Two minor components of pulmonary surfactant phospholipids, phosphatidylglycerol (PG) and phosphatidylinositol (PI), are present within the alveoli at very high concentrations, and exert anti-inflammatory effects by regulating multiple Toll like receptors (TLR2/1, TLR4, and TLR2/6) by antagonizing cognate ligand-dependent activation. POPG also attenuates LPS-induced lung injury in vivo. In addition, these lipids bind directly to RSV and influenza A viruses (IAVs) and block interaction between host cells and virions, and thereby prevent viral replication in vitro. POPG and PI also inhibit RSV and IAV infection in vivo, in mice and ferrets. The lipids markedly inhibit SARS-CoV-2 infection in vitro. These findings suggest that both POPG and PI have strong potential to be applied as both prophylaxis and post-infection treatments for problematic respiratory viral infections.
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DOI：
10.3390/molecules25173885
发表时间：
2020-08-26
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Borges-Araújo L;Fernandes F
通讯作者：
Fernandes F
DOI：
10.1164/rccm.200503-504oc
发表时间：
2005-10-15
影响因子：
24.7
作者：
Bullard, JE;Wert, SE;Nogee, LM
通讯作者：
Nogee, LM
影响因子：
120.7
作者：
Dharan, Nila J.;Gubareva, Larisa V.;Fry, Alicia M.
通讯作者：
Fry, Alicia M.
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
7.3
作者：
Floros J;Thorenoor N;Tsotakos N;Phelps DS
通讯作者：
Phelps DS