Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate.
Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate.
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DOI：
10.3390/molecules25173885
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发表时间：
2020-08-26
期刊：
影响因子：
--
通讯作者：
Fernandes F
中科院分区：
文献类型：
--
作者：
Borges-Araújo L;Fernandes F
磷脂酰肌醇 4,5-二磷酸 (PI(4,5)P2) 是真核细胞质膜内叶的次要但普遍存在的成分。然而，由于其特殊的复杂生物物理特性，它从邻近的脂质中脱颖而出，成为膜相关信号传导事件最重要的调节因子之一。尽管其稳态浓度非常低，PI(4,5)P2 能够同时参与多种细胞功能，这些功能通过膜中 PI(4,5)P2 局部瞬时池的存在在时间和空间上进行调节。这些池对于信号蛋白的招募、激活和组织以及下游信号传导的后续调节至关重要。本综述展示了一些最重要的 PI(4,5)P2 分子和生物物理特性及其对其膜动力学、横向组织以及与其他生化伙伴相互作用的影响。
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a minor but ubiquitous component of the inner leaflet of the plasma membrane of eukaryotic cells. However, due to its particular complex biophysical properties, it stands out from its neighboring lipids as one of the most important regulators of membrane-associated signaling events. Despite its very low steady-state concentration, PI(4,5)P2 is able to engage in a multitude of simultaneous cellular functions that are temporally and spatially regulated through the presence of localized transient pools of PI(4,5)P2 in the membrane. These pools are crucial for the recruitment, activation, and organization of signaling proteins and consequent regulation of downstream signaling. The present review showcases some of the most important PI(4,5)P2 molecular and biophysical properties as well as their impact on its membrane dynamics, lateral organization, and interactions with other biochemical partners.
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