Interneuronal mechanisms underlying a learning-induced switch in a sensory response that anticipates changes in behavioural outcomes
Interneuronal mechanisms underlying a learning-induced switch in a sensory response that anticipates changes in behavioural outcomes
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学习诱发的感觉反应转换的中间神经元机制，可预测行为结果的变化
DOI：
10.1101/2020.02.12.944553
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Pirger Z
中科院分区：
文献类型：
--
作者：
Pirger Z
动物对特定感官刺激的反应在很大程度上取决于与该刺激相关的先前经验。例如，厌恶性联想学习可能会导致预测结果的变化，从而抑制对奖励刺激的行为反应。然而，厌恶性学习如何导致抑制甚至是至关重要的先天行为的神经元机制却知之甚少。在这里，我们使用的模型系统ofarynaea stagnalisto解决的问题，如何预期的厌恶的结果可以改变行为反应，以前有效的喂养刺激。我们发现，以蔗糖为CS的厌恶性经典条件反射（条件刺激）和强烈的触摸作为厌恶的美国（无条件刺激）逆转了决定，使得相同的显著进食刺激抑制进食，而不是激活它。理解这种行为反应转换背后的神经机制的关键是PLB（胸膜颊）摄食网络的外部中间神经元，其对摄食回路的调节作用抑制摄食。在联想厌恶训练后，蔗糖可使PlB兴奋，从而逆转其对摄食反应的影响。厌恶性联想学习引起的持久性变化的电特性的PLB是足够的和必要的开关的行为输出。此外，在关联训练协议期间用作US的强烈触摸也可以用作敏化刺激，以导致对温和触摸刺激的增强的防御性退缩反应。这种非关联性的影响，强烈的触摸可能是基于促进兴奋性反应的PIB的尖峰活动在一个关键的识别interneuron的防御性撤退网络，Ped12。
How an animal responds to a particular sensory stimulus will to a great extent depend on prior experience associated with that stimulus. For instance, aversive associative learning may lead to a change in the predicted outcomes, which suppresses the behavioural response to an otherwise rewarding stimulus. However, the neuronal mechanisms of how aversive learning can result in the suppression of even a vitally important innate behaviour is much less understood. Here we used the model system ofLymnaea stagnalisto address the question of how an anticipated aversive outcome can alter the behavioural response to a previously effective feeding stimulus. We found that aversive classical conditioning with sucrose as the CS (conditioned stimulus) and strong touch as the aversive US (unconditioned stimulus) reverses the decision so that the same salient feeding stimulus inhibits feeding, rather than activating it. Key to the understanding of the neural mechanism underlying this switch in the behavioural response is the PlB (pleural buccal) extrinsic interneuron of the feeding network whose modulatory effects on the feeding circuit inhibit feeding. After associative aversive training, PlB is excited by sucrose to reverse its effects on the feeding response. Aversive associative learning induces a persistent change in the electrical properties of PlB that is both sufficient and necessary for the switch in the behavioral output. In addition, the strong touch used as the US during the associative training protocol can also serve as a sensitizing stimulus to lead to an enhanced defensive withdrawal response to a mild touch stimulus. This non-associative effect of the strong touch is probably based on the facilitated excitatory response of PlB to spike activity in a key identified interneuron of the defensive withdrawal network, PeD12.
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喂养网络中差异食欲经典调节的电相关性的选择性表达。
影响因子：
2.5
作者：
N. Jones;G. Kemenes;P. Benjamin
通讯作者：
P. Benjamin
影响因子：
2.5
作者：
Kemenes, G;Staras, K;Benjamin, PR
通讯作者：
Benjamin, PR
中枢运动模式与 Lymnaea stagnalis 摄食周期的关系。
影响因子：
2.8
作者：
R. M. Rose;P. Benjamin
通讯作者：
P. Benjamin
Lymnaea stagnalis 的全身戒断反应。
影响因子：
2.8
作者：
G. P. Ferguson;P. Benjamin
通讯作者：
P. Benjamin
DOI：
10.1016/s0163-1047(05)80067-6
发表时间：
1994-03-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
KEMENES, G;BENJAMIN, PR
通讯作者：
BENJAMIN, PR