Antiretroviral-based HIV prevention strategies for women.

Antiretroviral-based HIV prevention strategies for women.
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DOI:
10.1586/eri.10.79
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发表时间:
2010-10
影响因子:
5.7
通讯作者:
Parikh UM
Parikh UM
中科院分区:
医学2区
文献类型:
--
作者:
Chirenje ZM;Marrazzo J;Parikh UM

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自研究人员确定艾滋病毒是艾滋病的原因以来,已经过去了近三十年,联合国艾滋病规划署目前估计,2008年有3340万成年人感染艾滋病毒/艾滋病。这一疾病负担的三分之二在撒哈拉以南非洲,60%的感染者是妇女。这种疾病仍然无法治愈,目前的预防战略,包括禁欲、使用男用/女用避孕套和男性包皮环切术,只是部分有效。迫切需要遏制这一流行病的新战略。科学家们正在努力探索安全、有效和负担得起的艾滋病毒预防方法。这些新的生物干预措施包括使用口服抗逆转录病毒药物进行接触前预防、对艾滋病毒感染者进行抗逆转录病毒治疗以减少传播和局部使用抗逆转录病毒杀菌剂制剂。
Almost three decades have elapsed since researchers identified HIV as the cause of AIDS, with current estimates from UNAIDS that 33.4 million adults were living with HIV/AIDS in 2008. Two-thirds of this burden of disease is in Sub-Saharan Africa, and 60% of those infected are women. The disease still remains incurable and current prevention strategies including abstinence, male/female condom use and male circumcision are only partially effective. New strategies to curb the epidemic are urgently needed. Scientists are diligently exploring HIV prevention methods that are safe, effective and affordable. These new biological interventions include oral pre- exposure prophylaxis using oral antiretroviral (ARV) drugs, ARV treatment in HIV-infected persons to reduce transmission and topical ARV-based microbicide formulations.
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