Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference.
Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference.
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DOI：
10.1016/j.biopsych.2009.07.032
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发表时间：
2010-01-01
影响因子：
10.6
通讯作者：
Wood MA
中科院分区：
文献类型：
--
作者：
Malvaez M;Sanchis-Segura C;Vo D;Lattal KM;Wood MA
Recent evidence suggests that epigenetic mechanisms have an important role in the development of addictive behavior. However, little is known about the role of epigenetic mechanisms in the extinction of drug-induced behavioral changes. In this study we examined the ability of histone deacetylase (HDAC) inhibitors to facilitate extinction and attenuate reinstatement of cocaine-induced conditioned place preference (CPP). C57BL/6 mice were subject to cocaine-induced CPP using 20mg/kg dose. To facilitate extinction, mice were administered an HDAC inhibitor following non-reinforced exposure to the conditioned context. To measure persistence, mice were subject to a reinstatement test using 10mg/kg dose of cocaine. We demonstrate that HDAC inhibition during extinction consolidation can facilitate extinction of cocaine-induced CPP. Animals treated with an HDAC inhibitor extinguished cocaine-induced CPP both more quickly and to a greater extent than did vehicle-treated animals. We also show that the extinction of context-drug associated memories via HDAC inhibition modulates extinction learning such that reinstatement behavior is significantly attenuated. Acetylation of histone H3 in the nucleus accumbens following extinction was increased by HDAC inhibition. This study provides the first evidence that modulation of chromatin modification can facilitate extinction and prevent reinstatement of drug-induced behavioral changes. These findings provide a potential novel approach to the development of treatments that facilitate extinction of drug-seeking behavior.
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影响因子：
16.2
作者：
Miller, CA;Marshall, JF
通讯作者：
Marshall, JF
影响因子：
2
作者：
Milton, Amy L.;Lee, Jonathan L. C.;Everitt, Barry J.
通讯作者：
Everitt, Barry J.
影响因子：
10.6
作者：
Davis, Michael;Ressler, Kerry;Richardson, Rick
通讯作者：
Richardson, Rick
DOI：
10.1111/j.1530-0277.2009.00895.x
发表时间：
2009-05-01
影响因子：
3.2
作者：
Groblewski, Peter A.;Lattal, K. Matthew;Cunningham, Christopher L.
通讯作者：
Cunningham, Christopher L.
影响因子：
64.5
作者：
Guan, ZH;Giustetto, M;Kandel, ER
通讯作者：
Kandel, ER