Transmission of SARS-CoV-2 in the household setting: A prospective cohort study in children and adults in England.
Transmission of SARS-CoV-2 in the household setting: A prospective cohort study in children and adults in England.
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DOI：
10.1016/j.jinf.2021.07.037
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Lopez-Bernal J
中科院分区：
文献类型：
--
作者：
Miller E;Waight PA;Andrews NJ;McOwat K;Brown KE;Höschler K;Ijaz S;Letley L;Haskins D;Sinnathamby M;Cuthbertson H;Hallis B;Parimalanathan V;de Lusignan S;Lopez-Bernal J
测量在英格兰前瞻性随访的SARS-CoV-2感染的儿童和成人病例的家庭接触者中的二次发作率（SAR）。对PCR确诊的COVID-19病例的家庭接触者的自采鼻拭子和第35天的血液样本进行了检测，以确定是否感染SARS-CoV-2病毒。在172例有症状指示病例的431名接触者中，继发性发作率（SAR）为33%（95%置信区间[CI] 25-40），低于无呼吸道症状的原发病例，6%（CI 0-14）vs 37%（CI 29-45），p = 0.030。<11岁的索引病例的SAR为25%（CI 12-38）。SAR范围从<11岁接触者的16%（4-28）到19-54岁接触者的36%（CI 28-45）（p = 0.119）。感染者出现症状的比例（78%）与年龄相似（p = 0.44），尽管<19奥尔兹的人的平均症状数量少于成年人（p = 0.001），味觉或嗅觉丧失的报告较少（p = 0.0001）。：SARS-CoV-2病毒在家中传播的风险很高，包括由儿童引入感染的家庭。儿童受感染的风险低于成人，且较少出现典型的COVID-19感染症状。
To measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England. Self-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19 and blood samples on day 35 were tested for evidence of infection with SARS-CoV-2 virus. The secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases was 33% (95% confidence intervals [CI] 25–40) and was lower from primary cases without respiratory symptoms, 6% (CI 0–14) vs 37% (CI 29–45), p = 0.030. The SAR from index cases <11 years was 25% (CI 12–38). SARs ranged from 16% (4–28) in contacts <11 years old to 36% (CI 28–45) in contacts aged 19–54 years (p = 0.119). The proportion infected who developed symptoms (78%) was similar by age (p = 0.44) though <19 year olds had fewer mean number of symptoms than adults (p = 0.001) and fewer reported loss of sense of taste or smell (p = 0.0001). : There are high risks of transmission of SARS-CoV-2 virus in the home, including those where infection is introduced by a child. The risk of children acquiring infection was lower than that in adults and fewer developed typical symptoms of Covid-19 infection.
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影响因子：
19
作者：
Singanayagam, Anika;Patel, Monika;Gopal, Robin
通讯作者：
Gopal, Robin
DOI：
10.3138/jammi-2020-0030
发表时间：
2020-12-01
期刊：
Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada
影响因子：
--
作者：
Byambasuren, Oyungerel;Cardona, Magnolia;Glasziou, Paul
通讯作者：
Glasziou, Paul
影响因子：
7.7
作者：
Hall, J. A.;Harris, R. J.;Dunbar, J. K.
通讯作者：
Dunbar, J. K.
影响因子：
8.5
作者：
de Lusignan, Simon;Bernal, Jamie Lopez;Hobbs, Richard
通讯作者：
Hobbs, Richard
影响因子：
33.9
作者：
Grijalva, Carlos G.;Rolfes, Melissa A.;Talbot, Keipp
通讯作者：
Talbot, Keipp