Diffusion tractography predicts propagated high-frequency activity during epileptic spasms.
Diffusion tractography predicts propagated high-frequency activity during epileptic spasms.
复制标题
弥散纤维束成像预测癫痫痉挛时传播的高频活动。
DOI：
10.1111/epi.17251
复制
发表时间：
2022-07
期刊：
影响因子：
5.6
通讯作者：
Jeong, Jeong-Won
中科院分区：
文献类型：
--
作者：
O'Hara, Nolan B.;Lee, Min-Hee;Juhasz, Csaba;Asano, Eishi;Jeong, Jeong-Won
关键词：
确定癫痫痉挛事件期间限制发作性振荡传播的结构网络，并比较手术成功或不成功患者中观察到的传播模式。分析了18例年轻患者（年龄1-11岁）在癫痫痉挛事件期间的硬膜下电极记录，以确定发作网络并量化整个皮质表面的发作振荡的振幅和发作时间。通过接种与最早平均振荡起始时间相关的皮层区域，用弥散MRI纤维束成像产生相应的结构网络，并分离出连接发作网络内活性电极区域的白色物质通路。该结构网络的特性用于预测振荡起始时间和振幅，并在切除手术后实现和未实现癫痫发作自由的患者之间比较这种关系。在每例患者的痉挛事件中，发作传播模式相对一致。电极的平均发作振荡起始潜伏期与连接到具有最早平均振荡起始的区域的直接皮质皮质束的长度最显著相关（p <0.001，模型R2 = 0.54）。此外，发作振荡信号在皮质网络内传播更快的患者在切除手术后更有可能癫痫复发（p = 0.039）。发作振荡幅度也与连接追踪长度和沿这些通路的加权各向异性分数（FA）测量沿着相关（p = 0.002/0.030，模型R2 = 0.31/0.25）。类似的皮质丘脑通路的特点并没有表现出显着的协会与发作振荡的起始潜伏期或振幅。癫痫痉挛中高频活动的时空传播模式与起始皮质皮质通路的长度和FA测量一致。在这种个性化的框架中考虑数据可能有助于为手术决策和手术结果的预期提供信息。
Determine the structural networks that constrain propagation of ictal oscillations during epileptic spasm events, and compare observed propagation patterns across patients with successful or unsuccessful surgical outcomes. Subdural electrode recordings of 18 young patients (age 1–11 years) were analyzed during epileptic spasm events to determine ictal networks and quantify the amplitude and onset time of ictal oscillations across the cortical surface. Corresponding structural networks were generated with diffusion MRI tractography by seeding the cortical region associated with the earliest average oscillation onset time, and white matter pathways connecting active electrode regions within the ictal network were isolated. Properties of this structural network were used to predict oscillation onset times and amplitudes, and this relationship was compared across patients who did and did not achieve seizure freedom following resective surgery. Onset propagation patterns were relatively consistent across each patients’ spasm events. An electrode’s average ictal oscillation onset latency was most significantly associated with the length of direct corticocortical tracts connecting to the area with the earliest average oscillation onset (p < .001, model R2 = 0.54). Moreover, patients demonstrating a faster propagation of ictal oscillation signals within the corticocortical network were more likely to have seizure recurrence following resective surgery (p = .039). Ictal oscillation amplitude was also associated with connecting tractography length and weighted fractional anisotropy (FA) measures along these pathways (p = .002/.030, model R2 = 0.31/0.25). Characteristics of analogous corticothalamic pathways did not show significant associations with ictal oscillation onset latency or amplitude. Spatiotemporal propagation patterns of high-frequency activity in epileptic spasms align with length and FA measures from onset-originating corticocortical pathways. Considering data in this individualized framework may help inform surgical decision making and expectations of surgical outcomes.
登录
查看更多内容
影响因子：
4.7
作者：
Gardner, Andrew B.;Worrell, Greg A.;Litt, Brian
通讯作者：
Litt, Brian
影响因子：
29
作者：
Andrews, John P.;Gummadavelli, Abhijeet;Spencer, Dennis D.
通讯作者：
Spencer, Dennis D.
影响因子：
14.5
作者：
Shah, Preya;Ashourvan, Arian;Davis, Kathryn A.
通讯作者：
Davis, Kathryn A.
影响因子：
5.6
作者：
Nariai, Hiroki;Matsuzaki, Naoyuki;Asano, Eishi
通讯作者：
Asano, Eishi
DOI：
10.1016/j.nicl.2017.11.021
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Heers M;Helias M;Hedrich T;Dümpelmann M;Schulze-Bonhage A;Ball T
通讯作者：
Ball T