Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder
Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder
复制标题
腺苷对自闭症谱系障碍中少突胶质细胞和髓鞘形成的作用
DOI：
10.3389/fncel.2018.00482
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发表时间：
2018-12
影响因子：
5.3
通讯作者：
Xiao Lan
中科院分区：
文献类型：
--
作者：
Shen Hai Ying;Huang Nanxin;Reemmer Jesica;Xiao Lan
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction. Additionally, the neuromodulator adenosine has been shown to affect certain ASD comorbidities and symptoms, such as epilepsy, impairment of cognitive function, and anxiety. Adenosine is both directly and indirectly responsible for regulating the development of oligodendroglia and myelination through its interaction with, and modulation of, several neurotransmitters, including glutamate, dopamine, and serotonin. In this review, we will focus on the recent discoveries in adenosine interaction with physiological and pathophysiological activities of oligodendroglia and myelination, as well as ASD-related aspects of adenosine actions on neuroprotection and neuroinflammation. Moreover, we will discuss the potential therapeutic value and clinical approaches of adenosine manipulation against hypomyelination in ASD.
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影响因子：
6.2
作者：
T. Othman;Henglin Yan;S. Rivkees
通讯作者：
T. Othman;Henglin Yan;S. Rivkees
DOI：
10.1016/s0098-1672(08)70087-0
发表时间：
2007
期刊：
Yearbook of Diagnostic Radiology
影响因子：
--
作者：
A. Oestreich
通讯作者：
A. Oestreich
影响因子：
12.4
作者：
Boison, D.;Chen, J-F;Fredholm, B. B.
通讯作者：
Fredholm, B. B.
影响因子：
4.8
作者：
Kiese K;Jablonski J;Boison D;Kobow K
通讯作者：
Kobow K
选择性腺苷A2A受体激动剂和拮抗剂通过外周和中心作用预防脊髓损伤。
影响因子：
9.3
作者：
Paterniti I;Melani A;Cipriani S;Corti F;Mello T;Mazzon E;Esposito E;Bramanti P;Cuzzocrea S;Pedata F
通讯作者：
Pedata F