Regulation of TH17 cells in the mucosal surfaces.
Regulation of TH17 cells in the mucosal surfaces.
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DOI：
10.1016/j.jaci.2009.03.016
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发表时间：
2009-05
影响因子：
14.2
通讯作者：
Salek-Ardakani, Shahram
中科院分区：
文献类型：
--
作者：
Mucida, Daniel;Salek-Ardakani, Shahram
粘膜表面代表了有颌脊椎动物与环境之间的主要交叉点。肠的粘膜表面单独形成暴露于外源性抗原的最大表面以及体内淋巴组织的最大集合。因此，保护性免疫活性必须与有效的调节机制共存，以维持这些生物体的健康状态。产生白细胞介素（IL）-17的辅助性T细胞的新谱系的发现为宿主防御和粘膜表面炎性疾病的发病机制提供了有价值的新见解。对这些表面特别感兴趣的是，据报道，外周诱导的调节性T细胞和Th 17效应细胞以相互排斥的方式出现，这取决于它们是在TGF-β还是TGF-β加炎性细胞因子如IL-6存在下被激活。本文综述了Th 17细胞在粘膜表面的保护和致病作用以及控制其发展的潜在调控机制。
The mucosal surfaces represent the main intersection between jawed vertebrates and the environment. The mucosal surface of the intestine alone forms the largest surface that is exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the body. Therefore, a protective immune activity must coexist with efficient regulatory mechanisms in order to maintain a health status of these organisms. The discovery of a new lineage of helper T cells that produce interleukin (IL)-17 has provided valuable new insight into host defense and the pathogenesis of inflammatory diseases at the mucosal surfaces. Of particular interest for these surfaces, it has been reported that peripherally-induced regulatory T cells and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-β or TGF-β plus inflammatory cytokines such as IL-6. This review will address the protective and pathogenic roles of Th17 cells in the mucosal surfaces and potential regulatory mechanisms that control their development.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
DOI：
10.1084/jem.20080129
发表时间：
2009-01-16
期刊：
The Journal of experimental medicine
影响因子：
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影响因子：
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