Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
复制标题
DOI：
10.1084/jem.20080129
复制
发表时间：
2009-01-16
期刊：
影响因子：
--
通讯作者：
Sozzani S
中科院分区：
文献类型：
--
作者：
Albanesi C;Scarponi C;Pallotta S;Daniele R;Bosisio D;Madonna S;Fortugno P;Gonzalvo-Feo S;Franssen JD;Parmentier M;De Pità O;Girolomoni G;Sozzani S
银屑病是一种I型干扰素驱动的T细胞介导的疾病，其特征是浆细胞样树突状细胞(PDC)募集到皮肤中。银屑病皮损中参与PDC蓄积的分子尚不清楚。Chmerin是唯一一种在体外直接作用于人血PDC的炎性趋化因子。本研究的目的是评估趋化蛋白/ChemR23轴在银屑病皮肤中PDC募集中的作用。活动期和早期皮损附近的银屑病前期皮肤以真皮强表达趋化蛋白、CD15+中性粒细胞和CD123+/BDCA-2+/ChemR23+PDC为特征。相反，慢性斑块的皮肤显示低趋化蛋白表达，中性粒细胞分离为表皮微脓肿，真皮中几乎没有PDC。Chmerin主要定位于成纤维细胞、肥大细胞和内皮细胞。银屑病患者皮肤成纤维细胞表达的趋化蛋白信使RNA和蛋白水平高于非银屑病患者皮肤成纤维细胞和正常人皮肤成纤维细胞，并以趋化蛋白依赖的方式促进PDC在体外的迁移。因此，趋化蛋白的表达特异性地标志着银屑病皮损演变的早期阶段，并与PDC在时间上严格相关。这些结果支持趋化蛋白/趋化因子23轴在银屑病发展的早期阶段所起的作用。
Psoriasis is a type I interferon-driven T cell–mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into the skin. The molecules involved in pDC accumulation in psoriasis lesions are unknown. Chemerin is the only inflammatory chemotactic factor that is directly active on human blood pDC in vitro. The aim of this study was to evaluate the role of the chemerin/ChemR23 axis in the recruitment of pDC in psoriasis skin. Prepsoriatic skin adjacent to active lesions and early lesions were characterized by a strong expression of chemerin in the dermis and by the presence of CD15+ neutrophils and CD123+/BDCA-2+/ChemR23+ pDC. Conversely, skin from chronic plaques showed low chemerin expression, segregation of neutrophils to epidermal microabscesses, and few pDC in the dermis. Chemerin expression was localized mainly in fibroblasts, mast cells, and endothelial cells. Fibroblasts cultured from skin of psoriatic lesions expressed higher levels of chemerin messenger RNA and protein than fibroblasts from uninvolved psoriatic skin or healthy donors and promoted pDC migration in vitro in a chemerin-dependent manner. Therefore, chemerin expression specifically marks the early phases of evolving skin psoriatic lesions and is temporally strictly associated with pDC. These results support a role for the chemerin/ChemR23 axis in the early phases of psoriasis development.
登录
查看更多内容
影响因子：
30.5
作者：
Cella, M;Facchetti, F;Colonna, M
通讯作者：
Colonna, M
影响因子：
4.4
作者：
Jahnsen, FL;Lund-Johansen, F;Brandtzaeg, P
通讯作者：
Brandtzaeg, P
DOI：
10.1084/jem.20051035
发表时间：
2005-09-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Diacovo TG;Blasius AL;Mak TW;Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
82.9
作者：
Conrad, Curdin;Boyman, Onur;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
影响因子：
6.5
作者：
Rogalski, C;Meyer-Hoffert, U;Wiedow, O
通讯作者：
Wiedow, O