Virulence mechanisms and Cryptococcus neoformans pathogenesis.
Virulence mechanisms and Cryptococcus neoformans pathogenesis.
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DOI：
10.1016/j.fgb.2014.09.004
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Alspaugh JA
中科院分区：
文献类型：
--
作者：
Alspaugh JA
人类真菌病原体新型隐球菌能够快速有效地适应不同的条件，有利于其在环境和感染宿主中的生存。许多微生物表型与这种机会致病菌的毒力特别相关，如荚膜产生、黑色素形成和各种蛋白质的分泌。此外，细胞壁和形态发生等细胞特征在该真菌与宿主免疫识别和应答途径的相互作用中发挥重要作用。面对宿主压力的生存也需要保持RNA/DNA的完整性。此外，真菌细胞的老化和衰老决定了对宿主来源的胁迫的抗性。最近已经探索了调节这些毒力相关表型表达的新机制。重要的是，人类临床研究现在正在确认特定微生物因素在人类感染中的作用。
The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively adapt to varying conditions, favoring its survival in the environment and in the infected host. Many microbial phenotypes have been specifically correlated with virulence in this opportunistic pathogen, such as capsule production, melanin formation, and the secretion of various proteins. Additionally, cellular features such as the cell wall and morphogenesis play important roles in the interaction of this fungus with host immune recognition and response pathways. Survival in the face of host stress also requires maintaining RNA/DNA integrity. Additionally, aging and senescence of the fungal cells determines resistance to host-derived stresses. New mechanisms regulating the expression of these virulence-associated phenotypes have been recently explored. Importantly, human clinical studies are now confirming the roles of specific microbial factors in human infections.
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影响因子：
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作者：
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