A neural model of modified excitation/inhibition and feedback levels in schizophrenia.
A neural model of modified excitation/inhibition and feedback levels in schizophrenia.
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DOI：
10.3389/fpsyt.2023.1199690
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发表时间：
2023
影响因子：
4.7
通讯作者：
Yazdanbakhsh, Arash
中科院分区：
文献类型：
--
作者：
Zhu, Jiating;Zikopoulos, Basilis;Yazdanbakhsh, Arash
关键词：
某些视觉错觉的强度，包括对比和明显的运动，在精神分裂症患者身上减弱了。这种现象被解释为抑制性和兴奋性神经反应的整合受损，以及自上而下的反馈机制受损。为了研究这些因素是否以及如何影响精神分裂症患者的感知对比错觉和明显运动错觉，我们提出了一个双层网络，从第2层到第1层自上而下的反馈，可以模拟视觉感受野（RFs）及其抑制性和兴奋性子野。我们的神经模型表明，精神分裂症患者错觉感知的变化可能受到自上而下机制的改变和中心外接受野组织的影响。RF抑制环和/或兴奋中枢的改变可以复制精神分裂症患者在某些临床状态和正常对照之间的错觉知觉差异。结果表明，模拟的自顶向下反馈调制放大了模型错觉表征的差异，复制了两组之间的差异。我们认为，在精神分裂症的某些临床状态下，视觉和一般感觉加工的异质性在很大程度上可以用自上而下反馈的减少程度来解释，强调了自上而下反馈在错觉感知中的关键作用，并且在较小程度上解释了兴奋/抑制的不平衡。我们的神经模型为精神分裂症患者对比和明显运动的视觉知觉调节提供了一个机制解释，其发现可以解释先前研究中广泛的视觉知觉观察结果。当前模型的两层基序提供了一个总体框架，可用于研究皮质-皮层下（如丘脑皮质）和皮质-皮层网络，桥接精神分裂症和知觉加工中的神经生物学变化。
The strength of certain visual illusions, including contrast-contrast and apparent motion, is weakened in individuals with schizophrenia. Such phenomena have been interpreted as the impaired integration of inhibitory and excitatory neural responses, and impaired top–down feedback mechanisms. To investigate whether and how these factors influence the perceived contrast-contrast and apparent motion illusions in individuals with schizophrenia, we propose a two-layer network, with top-down feedback from layer 2 to layer 1 that can model visual receptive fields (RFs) and their inhibitory and excitatory subfields. Our neural model suggests that illusion perception changes in individuals with schizophrenia can be influenced by altered top-down mechanisms and the organization of the on-center off-surround receptive fields. Alteration of the RF inhibitory surround and/or the excitatory center can replicate the difference of illusion precepts between individuals with schizophrenia within certain clinical states and normal controls. The results show that the simulated top-down feedback modulation enlarges the difference of the model illusion representations, replicating the difference between the two groups. We propose that the heterogeneity of visual and in general sensory processing in certain clinical states of schizophrenia can be largely explained by the degree of top-down feedback reduction, emphasizing the critical role of top-down feedback in illusion perception, and to a lesser extent on the imbalance of excitation/inhibition. Our neural model provides a mechanistic explanation for the modulated visual percepts of contrast-contrast and apparent motion in schizophrenia with findings that can explain a broad range of visual perceptual observations in previous studies. The two-layer motif of the current model provides a general framework that can be tailored to investigate subcortico-cortical (such as thalamocortical) and cortico-cortical networks, bridging neurobiological changes in schizophrenia and perceptual processing.
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影响因子：
2.5
作者：
Cavanaugh, JR;Bair, W;Movshon, JA
通讯作者：
Movshon, JA
DOI：
10.1523/jneurosci.3620-15.2016
发表时间：
2017-02-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Anderson EJ;Tibber MS;Schwarzkopf DS;Shergill SS;Fernandez-Egea E;Rees G;Dakin SC
通讯作者：
Dakin SC
影响因子：
3.7
作者：
Qian J;Yazdanbakhsh A
通讯作者：
Yazdanbakhsh A
影响因子：
2.6
作者：
Crawford, T. J.;Hamm, J. P.;Ettinger, U.
通讯作者：
Ettinger, U.
影响因子：
2.5
作者：
Jones, HE;Grieve, KL;Sillito, AM
通讯作者：
Sillito, AM