Histologic development of the human fovea from midgestation to maturity.
Histologic development of the human fovea from midgestation to maturity.
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DOI：
10.1016/j.ajo.2012.05.007
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发表时间：
2012-11
影响因子：
4.2
通讯作者：
Toth, Cynthia A.
中科院分区：
文献类型：
--
作者：
Hendrickson, Anita;Possin, Daniel;Vajzovic, Lejla;Toth, Cynthia A.
描述人胚胎22 ~ 13岁视网膜中央部的组织学发育。回顾性观察病例系列视网膜层和神经元亚结构描绘在固定组织的中央凹切片染色的天青II-亚甲蓝和冷冻切片免疫标记的锥，杆或胶质蛋白。尸检组织来自Fwk 20-27时的11只眼; Fwk 28-37时的8只眼;出生后1天至6周时的6只眼; 9-15个月时的3只眼;以及28个月至13岁时的5只眼。在Fwk 20 -22，中央凹可以通过外核层中存在单层锥体来识别。免疫标记检测突触蛋白，视锥细胞和视杆细胞视蛋白和Muller神经胶质过程分离的光感受器。Fwk 25时，视网膜中央凹出现凹陷，包括神经节细胞、内丛状层和内核层的进行性外周移位。出生后，坑变宽变浅，15个月时成熟。Fwk 25和Fwk 38之间，所有的光感受器开发更明显的内部和外部段，但这些都比中央凹锥的外周更长。出生后，视锥细胞堆积，中心凹外核层增厚。锥包装和神经元迁移在坑形成相结合，形成长的中央感光轴突，这改变了外丛状层从一张薄薄的突触蒂到最厚的层在中央视网膜的15个月。15个月时，中心凹内段和外段长度与周边锥体匹配，13年时长4倍。这些数据对于了解人类视网膜从妊娠晚期到成年早期的显著变化是必要的。它们提供了定性和定量的形态学信息，用于解释相同年龄的儿科光谱域光学相干断层扫描（SDOCT）图像中超反射和低反射波段的变化。
To describe the histological development of the human central retina from fetal week (Fwk) 22 to 13 years. Retrospective observational case series Retinal layers and neuronal substructures were delineated on foveal sections of fixed tissue stained in azure II-methylene blue and on frozen sections immunolabeled for cone, rod or glial proteins. Postmortem tissue was from 11 eyes at Fwk 20–27; 8 eyes at Fwk 28–37; 6 eyes at postnatal 1 day to 6 weeks; 3 eyes at 9–15 months; and 5 eyes at 28 months-13 years. At Fwk20–22 the fovea could be identified by the presence of a single layer of cones in the outer nuclear layer. Immunolabeling detected synaptic proteins, cone and rod opsins and Muller glial processes separating the photoreceptors. The foveal pit appeared at Fwk25, involving progressive peripheral displacement of ganglion cell, inner plexiform and inner nuclear layers. The pit became wider and shallower after birth, and appeared mature by 15months. Between Fwk25 and Fwk38, all photoreceptors developed more distinct inner and outer segments, but these were longer on peripheral than foveal cones. After birth the foveal outer nuclear layer became much thicker as cone packing occurred. Cone packing and neuronal migration during pit formation combined to form long central photoreceptor axons, which changed the outer plexiform layer from a thin sheet of synaptic pedicles into the thickest layer in the central retina by 15 months. Foveal inner and outer segment length matched peripheral cones by 15 months and was 4× longer by 13 years. These data are necessary to understand the marked changes in human retina from late gestation to early adulthood. They provide qualitative and quantitative morphological information required to interpret the changes in hyper- and hypo-reflexive bands in pediatric spectral domain optical coherence tomography (SDOCT) images at the same ages.
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影响因子：
2.9
作者：
Nag, TC;Wadhwa, S
通讯作者：
Wadhwa, S
影响因子：
3.9
作者：
HENDRICKSON, A
通讯作者：
HENDRICKSON, A
影响因子：
56.9
作者：
ABRAMOV, I;GORDON, J;LABOSSIERE, E
通讯作者：
LABOSSIERE, E
影响因子：
2.5
作者：
Hendrickson, Anita;Troilo, David;Springer, Alan
通讯作者：
Springer, Alan
影响因子：
--
作者：
Provis, J. M.;Hendrickson, A. E.
通讯作者：
Hendrickson, A. E.