DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment.
DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment.
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DNA不匹配修复和氧化DNA损伤：对癌症生物学和治疗的影响。
DOI：
10.3390/cancers6031597
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发表时间：
2014-08-05
期刊：
影响因子：
5.2
通讯作者：
Martin SA
中科院分区：
文献类型：
--
作者：
Bridge G;Rashid S;Martin SA
细胞的许多成分，包括脂类、蛋白质以及核和线粒体DNA，都容易受到活性氧引起的有害修饰。如果不修复，氧化DNA损伤可能导致致病突变，例如癌症。碱基切除修复和核苷酸切除修复是两种DNA修复途径，被认为可以协调氧化损伤的清除。然而，最近的发现表明，错配修复途径可能对氧化DNA损伤的反应也很重要。这在癌症中尤其重要，因为错配修复基因经常发生突变或表观遗传沉默。在这篇综述中，我们探讨了错配修复蛋白对DNA氧化损伤的调节如何影响癌症的发生。我们讨论了最近的研究，这些研究确定了错配修复缺陷肿瘤的潜在新治疗方法，这些研究利用了使用合成致死靶向的错配修复的非典范作用。
Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations, such as in cancer. Base excision repair and nucleotide excision repair are the two DNA repair pathways believed to orchestrate the removal of oxidative lesions. However, recent findings suggest that the mismatch repair pathway may also be important for the response to oxidative DNA damage. This is particularly relevant in cancer where mismatch repair genes are frequently mutated or epigenetically silenced. In this review we explore how the regulation of oxidative DNA damage by mismatch repair proteins may impact on carcinogenesis. We discuss recent studies that identify potential new treatments for mismatch repair deficient tumours, which exploit this non-canonical role of mismatch repair using synthetic lethal targeting.
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影响因子：
4.7
作者：
Glaab, WE;Hill, RB;Skopek, TR
通讯作者：
Skopek, TR
DOI：
10.1016/j.mrgentox.2008.09.014
发表时间：
2009-03-31
影响因子：
1.9
作者：
Holt, Stewart M.;Scemama, Jean-Luc;Georgakilas, Alexandros G.
通讯作者：
Georgakilas, Alexandros G.
人类癌基因组中体细胞突变的模式。
影响因子：
64.8
作者：
Greenman, Christopher;Stephens, Philip;Smith, Raffaella;Dalgliesh, Gillian L.;Hunter, Christopher;Bignell, Graham;Davies, Helen;Teague, Jon;Butler, Adam;Edkins, Sarah;O'Meara, Sarah;Vastrik, Imre;Schmidt, Esther E.;Avis, Tim;Barthorpe, Syd;Bhamra, Gurpreet;Buck, Gemma;Choudhury, Bhudipa;Clements, Jody;Cole, Jennifer;Dicks, Ed;Forbes, Simon;Gray, Kris;Halliday, Kelly;Harrison, Rachel;Hills, Katy;Hinton, Jon;Jenkinson, Andy;Jones, David;Menzies, Andy;Mironenko, Tatiana;Perry, Janet;Raine, Keiran;Richardson, Dave;Shepherd, Rebecca;Small, Alexandra;Tofts, Calli;Varian, Jennifer;Webb, Tony;West, Sofie;Widaa, Sara;Yates, Andy;Cahill, Daniel P.;Louis, David N.;Goldstraw, Peter;Nicholson, Andrew G.;Brasseur, Francis;Looijenga, Leendert;Weber, Barbara L.;Chiew, Yoke-Eng;deFazio, Anna;Greaves, Mel F.;Green, Anthony R.;Campbell, Peter;Birney, Ewan;Easton, Douglas F.;Chenevix-Trench, Georgia;Tan, Min-Han;Khoo, Sok Kean;Teh, Bin Tean;Yuen, Siu Tsan;Leung, Suet Yi;Wooster, Richard;Futreal, P. Andrew;Stratton, Michael R.
通讯作者：
Stratton, Michael R.
影响因子：
11.2
作者：
Huang X;Dong Y;Bey EA;Kilgore JA;Bair JS;Li LS;Patel M;Parkinson EI;Wang Y;Williams NS;Gao J;Hergenrother PJ;Boothman DA
通讯作者：
Boothman DA
影响因子：
3.8
作者：
Barone, Flavia;McCulloch, Scott D.;Bignami, Margherita
通讯作者：
Bignami, Margherita