Patterns of somatic mutation in human cancer genomes.
Patterns of somatic mutation in human cancer genomes.
复制标题
人类癌基因组中体细胞突变的模式。
DOI：
10.1038/nature05610
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发表时间：
2007-03-08
期刊：
影响因子：
64.8
通讯作者：
Stratton, Michael R.
中科院分区：
文献类型：
--
作者：
Greenman, Christopher;Stephens, Philip;Smith, Raffaella;Dalgliesh, Gillian L.;Hunter, Christopher;Bignell, Graham;Davies, Helen;Teague, Jon;Butler, Adam;Edkins, Sarah;O'Meara, Sarah;Vastrik, Imre;Schmidt, Esther E.;Avis, Tim;Barthorpe, Syd;Bhamra, Gurpreet;Buck, Gemma;Choudhury, Bhudipa;Clements, Jody;Cole, Jennifer;Dicks, Ed;Forbes, Simon;Gray, Kris;Halliday, Kelly;Harrison, Rachel;Hills, Katy;Hinton, Jon;Jenkinson, Andy;Jones, David;Menzies, Andy;Mironenko, Tatiana;Perry, Janet;Raine, Keiran;Richardson, Dave;Shepherd, Rebecca;Small, Alexandra;Tofts, Calli;Varian, Jennifer;Webb, Tony;West, Sofie;Widaa, Sara;Yates, Andy;Cahill, Daniel P.;Louis, David N.;Goldstraw, Peter;Nicholson, Andrew G.;Brasseur, Francis;Looijenga, Leendert;Weber, Barbara L.;Chiew, Yoke-Eng;deFazio, Anna;Greaves, Mel F.;Green, Anthony R.;Campbell, Peter;Birney, Ewan;Easton, Douglas F.;Chenevix-Trench, Georgia;Tan, Min-Han;Khoo, Sok Kean;Teh, Bin Tean;Yuen, Siu Tsan;Leung, Suet Yi;Wooster, Richard;Futreal, P. Andrew;Stratton, Michael R.
癌症的产生是由于赋予生长优势的基因子集发生突变。人类基因组序列的可用性使我们提出，癌症基因组突变的系统性重新测序将导致许多其他癌症基因的发现。在这里，我们报告了在274 Mb的DNA中发现的1,000多个体细胞突变，对应于210种不同人类癌症中518个蛋白激酶基因的编码外显子。个体癌症中突变的数量和模式存在很大差异，反映了不同的暴露、DNA修复缺陷和细胞起源。大多数体细胞突变可能是“乘客”，不会导致肿瘤发生。然而，有证据表明，在大约120个基因中，“驱动”突变有助于癌症的发展。因此，癌症基因组的系统测序揭示了癌症的进化多样性，并暗示了比以前预期的更大的癌症基因库。
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers. There was substantial variation in the number and pattern of mutations in individual cancers reflecting different exposures, DNA repair defects and cellular origins. Most somatic mutations are likely to be ‘passengers’ that do not contribute to oncogenesis. However, there was evidence for ‘driver’ mutations contributing to the development of the cancers studied in approximately 120 genes. Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
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DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Sawyers, C
通讯作者：
Sawyers, C
影响因子：
64.8
作者：
Futreal, PA;Kasprzyk, A;Stratton, MR
通讯作者：
Stratton, MR
影响因子：
56.9
作者：
Bardelli, A;Parsons, DW;Velculescu, VE
通讯作者：
Velculescu, VE
影响因子：
11.2
作者：
Hunter C;Smith R;Cahill DP;Stephens P;Stevens C;Teague J;Greenman C;Edkins S;Bignell G;Davies H;O'Meara S;Parker A;Avis T;Barthorpe S;Brackenbury L;Buck G;Butler A;Clements J;Cole J;Dicks E;Forbes S;Gorton M;Gray K;Halliday K;Harrison R;Hills K;Hinton J;Jenkinson A;Jones D;Kosmidou V;Laman R;Lugg R;Menzies A;Perry J;Petty R;Raine K;Richardson D;Shepherd R;Small A;Solomon H;Tofts C;Varian J;West S;Widaa S;Yates A;Easton DF;Riggins G;Roy JE;Levine KK;Mueller W;Batchelor TT;Louis DN;Stratton MR;Futreal PA;Wooster R
通讯作者：
Wooster R