Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.
Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.
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DOI：
10.1177/1073858418805427
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发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Drew PJ;Winder AT;Zhang Q
动物和人类不断地进行小的、自发的运动动作，如眨眼、眨眼和姿势调整（“坐立不安”）。这些运动伴随着大脑感觉和运动区域神经活动的变化。这些运动的频率随时间变化，受感官刺激，唤醒水平和病理学的影响。这些坐立不安的行为可以被感官刺激所诱导。坐立不安的行为将导致在0.01到0.1 Hz频率范围内的神经活动的分布式、双侧功能激活，这将在功能磁共振成像和宽场钙神经成像研究中显示出来，并将有助于观察到的大脑区域之间的功能连接。然而，尽管这些行为有很大的潜力来驱动大脑的活动，但这些坐立不安的行为很少被监测。我们认为，对自发和诱发的大脑动力学的研究唤醒动物和人类应该密切监测这些坐立不安的行为。由于唤醒或病理导致的这些坐立不安行为的差异将“污染”正在进行的神经活动，并导致功能连接的明显差异。在实验过程中，为了区分坐立不安驱动的活动和内部驱动的神经动力学，监测和解释这些行为引起的全脑激活是必不可少的。
Animals and humans continuously engage in small, spontaneous motor actions, such as blinking, whisking, and postural adjustments (‘fidgeting’). These movements are accompanied by changes in neural activity in sensory and motor regions of the brain. The frequency of these motions varies in time, is affected by sensory stimuli, arousal levels, and pathology. These fidgeting behaviors can be entrained by sensory stimuli. Fidgeting behaviors will cause distributed, bilateral functional activation of neural activity in the 0.01 to 0.1 Hz frequency range that will show up in fMRI and wide-field calcium neuroimaging studies, and will contribute to the observed functional connectivity among brain regions. However, despite the large potential of these behaviors to drive brain-wide activity, these fidget-like behaviors are rarely monitored. We argue that studies of spontaneous and evoked brain dynamics awake animals and humans should closely monitor these fidgeting behaviors. Differences in these fidgeting behaviors due to arousal or pathology will ‘contaminate’ ongoing neural activity, and lead to apparent differences in functional connectivity. Monitoring and accounting for the brain-wide activations by these behaviors is essential during experiments in order to differentiate fidget-driven activity from internally-driven neural dynamics.
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DOI：
10.1056/nejmra0808281
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brown EN;Lydic R;Schiff ND
通讯作者：
Schiff ND
影响因子：
4.8
作者：
Birn, Rasmus M.;Murphy, Kevin;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
影响因子：
5.3
作者：
Cardin, JA;Schmidt, MF
通讯作者：
Schmidt, MF
影响因子：
9.2
作者：
Blumberg, Mark S.;Coleman, Cassandra M.;McMurray, Bob
通讯作者：
McMurray, Bob
影响因子：
15.9
作者：
Brenowitz EA;Zakon HH
通讯作者：
Zakon HH