A model‐based reconstruction technique for quantitative myocardial perfusion imaging
A model‐based reconstruction technique for quantitative myocardial perfusion imaging
复制标题
基于模型的定量心肌灌注成像重建技术
DOI：
10.1002/mrm.25921
复制
发表时间：
2016
影响因子：
3.3
通讯作者：
Köstler H
中科院分区：
文献类型：
--
作者：
Tran-Gia J;Lohr D;Weng AM;Ritter CO;Stäb D;Bley TA;Köstler H
目的采用基于模型的重建方法，减少定量心肌第一次饱和恢复灌注成像中动脉输入函数（AIF）估计中的饱和影响。原理与方法采用饱和恢复制备的径向FLASH序列进行成像。采用基于模型的重建方法进行重建。利用松弛过程的先验知识，重构了具有不同饱和度恢复时间的图像序列。通过评估有效饱和时间约为3 ms的图像，降低了AIF测定中的饱和效应。在一项志愿者研究中，将这种方法与标准的预注射技术进行了比较。结果与低剂量注射前丸相比，使用基于模型的方法确定的aif中的饱和效应进一步降低。这些影响在所有6名志愿者身上都清晰可见，在绝对灌注值上有高达20%的统计学显著差异。结论基于模型的重建算法在定量心肌灌注成像中的应用，可显著提高心肌缺血坏死因子的测定。除了大大减少饱和效应，甚至发生在前丸方法，只有一个丸剂必须应用。中华医学杂志（英文版），2016。©2015 Wiley期刊公司
PurposeTo reduce saturation effects in the arterial input function (AIF) estimation of quantitative myocardial first‐pass saturation recovery perfusion imaging by employing a model‐based reconstruction.Theory and MethodsImaging was performed with a saturation recovery prepared radial FLASH sequence. A model‐based reconstruction was applied for reconstruction. By exploiting prior knowledge about the relaxation process, an image series with different saturation recovery times was reconstructed. By evaluating images with an effective saturation time of approximately 3 ms, saturation effects in the AIF determination were reduced. In a volunteer study, this approach was compared with a standard prebolus technique.ResultsIn comparison to the low‐dose injection of a prebolus acquisition, saturation effects were further reduced in the AIFs determined using the model‐based approach. These effects, which were clearly visible for all six volunteers, were reflected in a statistically significant difference of up to 20% in the absolute perfusion values.ConclusionThe application of model‐based reconstruction algorithms in quantitative myocardial perfusion imaging promises a significant improvement of the AIF determination. In addition to greatly reducing saturation effects that occur even for the prebolus methods, only a single bolus has to be applied. Magn Reson Med 76:880–887, 2016. © 2015 Wiley Periodicals, Inc.
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