Astrocytes as Perspective Targets of Exercise- and Caloric Restriction-Mimetics.
Astrocytes as Perspective Targets of Exercise- and Caloric Restriction-Mimetics.
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星形胶质细胞作为运动和热量限制模拟物的潜在靶点。
DOI：
10.1007/s11064-021-03277-2
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发表时间：
2021-10
影响因子：
4.4
通讯作者：
Pankratov Y
中科院分区：
文献类型：
--
作者：
Lalo U;Pankratov Y
增强的精神和身体活动可以对实验动物和人类患者的衰老大脑功能产生积极影响，尽管这些影响的细胞机制目前尚不清楚。越来越多的证据表明，许多神经退行性疾病的临床前阶段涉及星形胶质细胞和神经元之间相互作用的变化。相反，星形胶质细胞在战略上被定位为介导身体活动和饮食对神经元功能的积极影响。因此，开发能够改善衰老大脑中星形胶质细胞-神经元通讯的治疗药物至关重要。脑寿命的细胞机制研究的最新进展表明，星形胶质细胞-神经元通信在热量限制、体育锻炼及其药理学模拟物对突触稳态和认知功能的有益作用中具有至关重要的作用。特别是，我们最近的数据表明，去甲肾上腺素摄取抑制剂托莫西汀可以增强星形胶质细胞Ca 2+信号和星形胶质细胞驱动的突触可塑性调节。热量限制模拟剂二甲双胍和白藜芦醇也表现出类似的效果。出现的数据还表明，星形胶质细胞可能参与了热量限制及其模拟物对神经元自噬的调节作用。尽管如此，星形胶质细胞靶向化合物在预防与年龄相关的认知能力下降方面的效率还有待充分探索，特别是在神经退行性疾病和自噬损伤的动物模型中。
Enhanced mental and physical activity can have positive effects on the function of aging brain, both in the experimental animals and human patients, although cellular mechanisms underlying these effects are currently unclear. There is a growing evidence that pre-clinical stage of many neurodegenerative diseases involves changes in interactions between astrocytes and neurons. Conversely, astrocytes are strategically positioned to mediate the positive influence of physical activity and diet on neuronal function. Thus, development of therapeutic agents which could improve the astroglia-neuron communications in ageing brain is of crucial importance. Recent advances in studies of cellular mechanisms of brain longevity suggest that astrocyte-neuron communications have a vital role in the beneficial effects of caloric restriction, physical exercise and their pharmacological mimetics on synaptic homeostasis and cognitive function. In particular, our recent data indicate that noradrenaline uptake inhibitor atomoxetine can enhance astrocytic Ca2+-signaling and astroglia-driven modulation of synaptic plasticity. Similar effects were exhibited by caloric restriction-mimetics metformin and resveratrol. The emerged data also suggest that astrocytes could be involved in the modulatory action of caloric restriction and its mimetics on neuronal autophagy. Still, the efficiency of astrocyte-targeting compounds in preventing age-related cognitive decline is yet to be fully explored, in particular in the animal models of neurodegenerative diseases and autophagy impairment.
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影响因子：
19
作者：
Funderburk SF;Wang QJ;Yue Z
通讯作者：
Yue Z
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
影响因子：
4.6
作者：
Hiasa M;Miyaji T;Haruna Y;Takeuchi T;Harada Y;Moriyama S;Yamamoto A;Omote H;Moriyama Y
通讯作者：
Moriyama Y
DOI：
10.1113/jp278761
发表时间：
2021-03
期刊：
The Journal of physiology
影响因子：
--
作者：
Hawley JA;Joyner MJ;Green DJ
通讯作者：
Green DJ
DOI：
10.1038/s41580-018-0033-y
发表时间：
2018-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Hansen M;Rubinsztein DC;Walker DW
通讯作者：
Walker DW