Effect of the COVID-19 Lockdown on Asthma Biological Rhythms.
Effect of the COVID-19 Lockdown on Asthma Biological Rhythms.
复制标题
DOI：
10.1177/07487304221081730
复制
发表时间：
2022-04
影响因子：
3.5
通讯作者：
Haspel, Jeffrey
中科院分区：
文献类型：
--
作者：
Hazan, Guy;Fox, Carolyn;Eiden, Elise;Anderson, Neil;Friger, Michael;Haspel, Jeffrey
哮喘具有显著的时间特征，其中一天中的时间、患者年龄和季节均影响疾病活动。哮喘活动的节律在多大程度上反映了暴露于特定疾病触发因素仍不清楚。在这项研究中，我们研究了COVID-19大流行期间制定的病毒缓解策略（“封锁措施”）如何影响儿童哮喘临床活动的节律。为此，我们回顾性分析了我们地区学术医疗中心18岁以下儿童的哮喘临床表现，比较了COVID-19封锁措施前4年的医疗记录与采取此类措施后12个月的医疗记录。我们将这些数据与同一时间段内的阳性病毒检测结果、热性惊厥和过敏临床替代物（分别为过敏反应访视和艾德抗组胺药处方）相关联。在COVID-19封锁后的12个月内，与COVID-19前相比，常见呼吸道病毒的阳性率下降了70. 2%，儿童哮喘的艾德就诊率下降了62%。锁定抑制了阳性病毒检测和哮喘艾德访视的季节性变化，而哮喘访视的昼夜节律不变。在COVID封锁措施实施前后，哮喘季节性与鼻病毒阳性相关性最强。总之，我们的数据支持病毒在驱动儿童哮喘急性发作的季节性变化中的因果作用。
Asthma has a striking temporal character, in which time-of-day, patient age, and season each influence disease activity. The extent to which rhythms in asthma activity reflect exposure to specific disease triggers remains unclear. In this study, we examined how virus mitigation strategies enacted during the COVID-19 pandemic (“lockdown measures”) affected rhythms in asthma clinical activity in children. To this end, we retrospectively analyzed asthma clinical presentations in children <18 years old to our regional academic medical center, comparing 4 years of medical records prior to COVID-19 lockdown measures to the 12 months immediately after the institution of such measures. We correlated these data to positive viral test results, febrile seizures, and allergic clinical surrogates (allergic reaction visits, and ED antihistamine prescriptions, respectively) over the same timeframe. In the 12 months following the institution of COVID-19 lockdown, positivity rates for common respiratory viruses dropped by 70.2% and ED visits for asthma among children dropped by 62% compared to pre-COVID years. Lockdown suppressed seasonal variation in positive viral tests and asthma ED visits, while diurnal rhythms in asthma visits was unchanged. Asthma seasonality correlated most strongly with rhinovirus positivity both before and after the institution of COVID lockdown measures. Altogether, our data supports a causal role for viruses in driving seasonal variability in asthma exacerbations in children.
登录
查看更多内容
影响因子：
8
作者：
Cohen, Herman Avner;Blau, Hannah;Balicer, Ran D.
通讯作者：
Balicer, Ran D.
影响因子：
6.1
作者：
Friger, Michael;Shoham-Vardi, Ilana;Abu-Saad, Kathleen
通讯作者：
Abu-Saad, Kathleen
影响因子：
33.9
作者：
Moreland, Amanda;Herlihy, Christine;Baldwin, Grant
通讯作者：
Baldwin, Grant
影响因子：
14.2
作者：
Lynch, Jason P.;Werder, Rhiannon B.;Phipps, Simon
通讯作者：
Phipps, Simon
影响因子：
4.4
作者：
Han, Yueh-Ying;Lee, Yung-Ling;Guo, Yueliang Leon
通讯作者：
Guo, Yueliang Leon