Cognitive Performance Profile in Pediatric Moyamoya Disease Patients and Its Relationship With Regional Cerebral Blood Perfusion
Cognitive Performance Profile in Pediatric Moyamoya Disease Patients and Its Relationship With Regional Cerebral Blood Perfusion
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儿童烟雾病患者的认知表现及其与局部脑血流灌注的关系
DOI：
10.3389/fneur.2019.01308
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发表时间：
2019-12
影响因子：
3.4
通讯作者：
Zhao Jizong
中科院分区：
文献类型：
--
作者：
Li Jiaxi;Liu Xingju;Zhang Dong;Zhang Yan;Wang Rong;Yuan Jing;Zhao Jizong
目的：烟雾病影响儿童的认知功能，脑血流量减少可能是其潜在原因。我们的目的是探讨儿童烟雾病患者的认知功能障碍和局部灌注状态之间的特定相关性。方法：我们前瞻性纳入了2017年7月至2019年3月在北京天坛医院住院的连续儿童烟雾病患者。对所有受试者进行动脉自旋标记磁共振检查和韦氏儿童智力量表（第4版）。分析患者的认知表现，并在基于兴趣区的分析中研究其与脑灌注状态的相关性。结果：21例患者符合纳入标准，平均年龄（11.14 ± 2.82）岁，男：女= 11：10。6例患者（28.6%）在任何指数评分中均未显示认知缺陷，而15例（71.4%）显示不同严重程度的认知缺陷。9例（42.9%）患者表现为整体认知功能障碍，除言语理解指数外，其余认知指标均显著低于相应年龄的正常值。经影像学证实的脑梗死患者的感知推理指数（p = 0.019）在统计学上较低。左半球的Suzuki分期与全面智商呈负相关（r =-0.452，p = 0.039）。感兴趣区分析显示左颞叶脑血流与加工速度指数独立相关（β = 0.535，p = 0.041）。结论：烟雾病患儿存在不同程度的认知功能障碍。脑梗死与知觉推理能力差有关。左颞叶脑血流量与加工速度呈正相关。
Object: Moyamoya disease affects the cognitive function of pediatric patients, and compromised cerebral blood flow might be the potential cause. We aimed to explore the specific correlation between cognitive impairment and regional perfusion status in pediatric moyamoya disease patients. Methods: We prospectively enrolled consecutive pediatric moyamoya disease patients admitted to Beijing Tiantan Hospital from July 2017 to March 2019. Arterial spin-labeling magnetic resonance and the Wechsler Intelligence Scale for Children (the 4th edition) were performed on all participants. The cognitive performance of patients was analyzed, and its correlation to cerebral perfusion status was also investigated in the region of interest-based analysis. Results: A total of 21 patients met the inclusion criteria (mean aged 11.14 ± 2.82, male: female = 11:10). Six patients (28.6%) showed no cognitive deficits in any index score, while 15 (71.4%) showed cognitive deficits with differing severity. Nine (42.9%) patients showed overall cognitive impairment, and all cognitive index scores except for Verbal Comprehension Index were significantly lower than the mean scores of normative data with corresponding age. Perceptual Reasoning Index (p = 0.019) were statistically lower in patients with radiologically confirmed cerebral infarction. Suzuki stage of the left hemisphere negatively correlated to Full-scale Intelligence Quotient (r = −0.452, p = 0.039). Region of Interest analysis showed that cerebral blood flow of the left temporal lobe independently associated with the Processing Speed Index (β = 0.535, p = 0.041). Conclusion: Pediatric moyamoya disease patients exhibited different levels of cognitive impairment. Cerebral infarction is related to poorer perceptual reasoning ability. Cerebral blood flow in the left temporal lobe positively correlates with processing speed.
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影响因子：
8.2
作者：
Kim JS
通讯作者：
Kim JS
影响因子：
3.8
作者：
T. Kurokawa;S. Tomita;K. Ueda;O. Narazaki;T. Hanai;K. Hasuo;T. Matsushima;K. Kitamura
通讯作者：
T. Kurokawa;S. Tomita;K. Ueda;O. Narazaki;T. Hanai;K. Hasuo;T. Matsushima;K. Kitamura
影响因子：
4.8
作者：
J. Lancaster;M. Woldorff;L. Parsons;M. Liotti;C. Freitas;L. Rainey;P. Kochunov;D. Nickerson;S. Mikiten;P. Fox
通讯作者：
J. Lancaster;M. Woldorff;L. Parsons;M. Liotti;C. Freitas;L. Rainey;P. Kochunov;D. Nickerson;S. Mikiten;P. Fox
DOI：
10.12771/emj.2013.36.1.9
发表时间：
2013-03
期刊：
The Ewha Medical Journal
影响因子：
--
作者：
E. Seo
通讯作者：
E. Seo
影响因子：
4.8
作者：
Bangen KJ;Werhane ML;Weigand AJ;Edmonds EC;Delano-Wood L;Thomas KR;Nation DA;Evangelista ND;Clark AL;Liu TT;Bondi MW
通讯作者：
Bondi MW