Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.

Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.
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小鼠中影响可的松引起的腭裂易感性的基因与 2 号和 17 号染色体上的 Ir 基因密切相关。

DOI:
10.1073/pnas.78.5.3147
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发表时间:
1981
影响因子:
11.1
通讯作者:
Goldman,AS
Goldman,AS
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Gasser,DL;Mele,L;Lees,DD;Goldman,AS

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近亲繁殖和同系型小鼠对可的松诱发的腭裂的易感性进行了研究,并证实了17号染色体上与H-2相关的基因的作用。H-2d、H-2b、H-2k和H-2a单倍型分别具有较高的易感性,H-2q和H-2s也具有较高的易感性。有证据表明,一个基因位于H-2的B区,另一个与H-2相关的基因通过互补作用位于e区右侧,另一个影响该性状的基因与第二染色体上的H-3和Ir-2位点密切相关。
Inbred and congeneic strains of mice have been examined for susceptibility to cortisone-induced cleft palate, and the role of genes linked to H-2 on chromosome 17 has been confirmed. Increasing degrees of susceptibility were associated with the H-2d, H-2b, H-2k, and H-2a haplotypes, respectively, with H-2q and H-2s also being associated with fairly high levels of susceptibility. Evidence was obtained that suggests that one gene maps within the B region of H-2, and that a second H-2 linked gene which acts by complementation maps to the right of E. Another gene affecting this trait is closely linked to the H-3 and Ir-2 loci on the second chromosome.
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