Scan-rescan reproducibility of quantitative assessment of inflammatory carotid atherosclerotic plaque using dynamic contrast-enhanced 3T CMR in a multi-center study.
Scan-rescan reproducibility of quantitative assessment of inflammatory carotid atherosclerotic plaque using dynamic contrast-enhanced 3T CMR in a multi-center study.
复制标题
DOI：
10.1186/s12968-014-0051-7
复制
发表时间：
2014-08-01
期刊：
影响因子：
--
通讯作者：
Zhao XQ
中科院分区：
文献类型：
--
作者：
Chen H;Sun J;Kerwin WS;Balu N;Neradilek MB;Hippe DS;Isquith D;Xue Y;Yamada K;Peck S;Yuan C;O'Brien KD;Zhao XQ
本研究的目的是利用动态对比增强（DCE）心血管磁共振（CMR）在3T多中心环境下研究动脉粥样硬化斑块动力学参数的扫描间再现性。使用先前描述的DCE-CMR协议，在两周内对来自15个地点的51名受试者的颈动脉进行两次3T扫描仪扫描。分析符合协议和足够图像质量的成像数据，生成血管壁的动力学参数，用传递常数（Ktrans）和等离子体体积（vp）表示。采用类内相关系数（ICC）和变异系数（CV）评价扫描间重复性。进行功率分析，为未来的前瞻性研究提供样本量估计。发现10例（19.6%）受试者违反了协议，另有6例（11.8%）至少在一次扫描中图像质量较差（n = 6）。在35例（68.6%）资料完整的受试者中，Ktrans和vp的ICCs分别为0.65和0.28。简历值分别为25%和62%。在分析面积大于25 mm2的较大病变中，vp的ICC和CV分别提高到0.73和28%。基于测量CV的功率分析显示，在不考虑退出率的情况下，在功率为80%的治疗组之间，每组50名受试者足以检测到Ktrans随时间变化的20%差异。本研究结果表明，尽管存在局限性，但在前瞻性多中心研究中，DCE-CMR定量测量在相对适度的样本量下检测变化是可行的。相对较高的辍学率表明，在未来的研究中，迫切需要加强操作员培训、优化成像方案和严格的质量控制。
The aim of this study is to investigate the inter-scan reproducibility of kinetic parameters in atherosclerotic plaque using dynamic contrast-enhanced (DCE) cardiovascular magnetic resonance (CMR) in a multi-center setting at 3T. Carotid arteries of 51 subjects from 15 sites were scanned twice within two weeks on 3T scanners using a previously described DCE-CMR protocol. Imaging data with protocol compliance and sufficient image quality were analyzed to generate kinetic parameters of vessel wall, expressed as transfer constant (Ktrans) and plasma volume (vp). The inter-scan reproducibility was evaluated using intra-class correlation coefficient (ICC) and coefficient of variation (CV). Power analysis was carried out to provide sample size estimations for future prospective study. Ten (19.6%) subjects were found to suffer from protocol violation, and another 6 (11.8%) had poor image quality (n = 6) in at least one scan. In the 35 (68.6%) subjects with complete data, the ICCs of Ktrans and vp were 0.65 and 0.28, respectively. The CVs were 25% and 62%, respectively. The ICC and CV for vp improved to 0.73 and 28% in larger lesions with analyzed area larger than 25 mm2. Power analysis based on the measured CV showed that 50 subjects per arm are sufficient to detect a 20% difference in change of Ktrans over time between treatment arms with 80% power without consideration of the dropout rate. The result of this study indicates that quantitative measurement from DCE-CMR is feasible to detect changes with a relatively modest sample size in a prospective multi-center study despite the limitations. The relative high dropout rate suggested the critical needs for intensive operator training, optimized imaging protocol, and strict quality control in future studies.
登录
查看更多内容
影响因子：
14
作者：
Vucic, Esad;Dickson, Stephen D.;Calcagno, Claudia;Rudd, James H. F.;Moshier, Erin;Hayashi, Katsumi;Mounessa, Jessica S.;Roytman, Michelle;Moon, Matthew J.;Lin, James;Tsimikas, Sotirios;Fisher, Edward A.;Nicolay, Klaas;Fuster, Valentin;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
影响因子：
4.3
作者：
McCarthy, MJ;Loftus, IM;Brindle, NPJ
通讯作者：
Brindle, NPJ
影响因子：
19.7
作者：
Kerwin, William S.;O'Brien, Kevin D.;Yuan, Chun
通讯作者：
Yuan, Chun
F-18-氟脱氧葡萄糖正电子发射断层扫描和动态增强 MRI 之间不同的相关性对颈动脉粥样硬化斑块炎症的影响
影响因子：
8.3
作者：
Wang, Juan;Liu, Hongbin;Chen, Huijun
通讯作者：
Chen, Huijun
影响因子：
8.3
作者：
Sun J;Song Y;Chen H;Kerwin WS;Hippe DS;Dong L;Chen M;Zhou C;Hatsukami TS;Yuan C
通讯作者：
Yuan C