Contraceptive methods and fertility testing in young adult survivors of childhood cancer.
Contraceptive methods and fertility testing in young adult survivors of childhood cancer.
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DOI：
10.1007/s10815-023-02908-7
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发表时间：
2023-10
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
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作者：
生殖健康很重要，但在癌症幸存者护理中往往被忽视。本研究探讨了德国儿童癌症的年轻成年幸存者中避孕药具的使用及其与生育测试相关的因素。通过德国儿童癌症登记处确定了儿童癌症的年轻成年幸存者，并完成了一项邮寄调查。幸存者被问及避孕药具的使用、生育目标、生育能力的不确定性、生育能力测试的完成或兴趣。使用多变量逐步逻辑回归模型来计算优势比（OR）和95%置信区间（CI），作为识别与生育测试完成和兴趣相关的因素的手段。幸存者（N = 472, 57.8%为女性，诊断年龄23.3±1.5岁，14.9±5.0岁）的避孕药具使用率较高，其中61.2%使用单一方法，30.6%使用双重方法，8.1%无效或无效。很少有幸存者完成了生育测试（13.0%），尽管58.8%的人感兴趣。在青春期确诊（OR = 2.66, 95%CI: 1.39-5.09）、对生育能力的不确定性（OR = 1.16, 95%CI: 1.03-1.31）和使用双重避孕方法（OR = 1.94, 95%CI: 1.02-3.69）与完成生育测试相关。对生育测试感兴趣的相关因素包括想要孩子的目标（OR = 7.76, 95%CI: 3.01-20.04）和生育能力的不确定性（OR = 1.19 95%CI: 1.06-1.33）。在这个从儿童癌症中幸存下来的年轻人样本中，大多数报告使用了避孕措施。很少有幸存者完成了生育测试，尽管有一半以上的人对此感兴趣。需要采取干预措施，以解决生育检测的潜在障碍，并帮助幸存者管理与生育有关的不确定性。
Reproductive health is important, but often neglected in cancer survivorship care. This study explored contraceptive use and factors associated with fertility testing among young adult survivors of childhood cancer in Germany. Young adult survivors of childhood cancer were identified through the German Childhood Cancer Registry and completed a mailed survey. Survivors were queried regarding contraceptive use, reproductive goals, uncertainty about fertility, and completion or interest in fertility testing. Multivariable stepwise logistic regression models were used to calculate Odds Ratios (OR) and 95% confidence intervals (CI) as a means of identifying factors associated with completion of and interest in fertility testing. Survivors (N = 472; 57.8% female; aged 23.3 ± 1.5 years, and 14.9 ± 5.0 years from diagnosis), reported high rates of contraceptive use, including 61.2% using a single method, 30.6% dual methods, and 8.1% no/less effective methods. Few survivors had completed fertility testing (13.0%), although 58.8% were interested. Having been diagnosed during adolescence (OR = 2.66, 95%CI: 1.39–5.09), greater uncertainty about fertility (OR = 1.16, 95%CI: 1.03–1.31), and use of dual contraceptive methods (OR = 1.94, 95%CI: 1.02–3.69) were associated with having completed fertility testing. Factors associated with interest in fertility testing included goals of wanting to have children (OR = 7.76, 95%CI: 3.01–20.04) and greater uncertainty about fertility (OR = 1.19 95%CI: 1.06–1.33). In this sample of young adults who survived childhood cancer, most reported contraceptive use. Few survivors had completed fertility testing, although more than half were interested. Interventions are needed to address potential barriers to fertility testing and help survivors manage fertility-related uncertainty.
DOI：
10.25646/9873
发表时间：
2022-06
期刊：
Journal of health monitoring
影响因子：
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作者：
Hintzpeter, Birte;Krause, Laura;Vogelgesang, Felicitas;Prutz, Franziska
通讯作者：
Prutz, Franziska
年轻成人癌症幸存者中的性行为和人乳头瘤病毒疫苗不可生化。
DOI：
10.1007/s11764-021-01000-2
发表时间：
2021-12
期刊：
Journal of cancer survivorship : research and practice
影响因子：
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作者：
Cherven B;Klosky JL;Chen Y;York JM;Heaton K;Childs G;Flynn JS;Connelly JA;Wasilewski-Masker K;Robison LL;Hudson MM;Wong FL;Bhatia S;Landier W
通讯作者：
Landier W