Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
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DOI：
10.1016/j.drudis.2021.02.009
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发表时间：
2021-06
影响因子：
7.4
通讯作者：
Giorgini F
中科院分区：
文献类型：
--
作者：
Collier ME;Zhang S;Scrutton NS;Giorgini F
导致 2019 年冠状病毒病 (COVID-19) 的新型呼吸道病毒严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 于 2019 年末出现并在世界各地迅速传播。现在人们认识到神经系统可能会受到 COVID-19 的影响，多项研究报告了患者的长期认知问题。色氨酸降解的代谢途径，即犬尿氨酸途径 (KP)，在 COVID-19 患者中显着激活。 KP 代谢物在调节炎症/免疫反应和神经功能中发挥作用。在这篇综述中，我们推测 KP 激活对 COVID-19 患者的影响，以及调节该通路如何影响炎症并减轻神经系统症状。 2019 年冠状病毒 (COVID-19) 患者中色氨酸降解的犬尿氨酸途径被激活。讨论了犬尿氨酸代谢物对 COVID-19 炎症和神经认知的可能影响，以及犬尿氨酸 3-单加氧酶抑制剂治疗的潜在用途。
The novel respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), emerged during late 2019 and spread rapidly across the world. It is now recognised that the nervous system can be affected in COVID-19, with several studies reporting long-term cognitive problems in patients. The metabolic pathway of tryptophan degradation, known as the kynurenine pathway (KP), is significantly activated in patients with COVID-19. KP metabolites have roles in regulating both inflammatory/immune responses and neurological functions. In this review, we speculate on the effects of KP activation in patients with COVID-19, and how modulation of this pathway might impact inflammation and reduce neurological symptoms. The kynurenine pathway of tryptophan degradation is activated in patients with Coronavirus 2019 (COVID-19). The possible effects of kynurenine metabolites on inflammation and neurocognition in COVID-19 and the potential use of kynurenine 3-monooxygenase inhibitors for treatment are discussed.
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