Adventitial fibroblasts: backstage journeymen.

Adventitial fibroblasts: backstage journeymen.
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外膜成纤维细胞:后台熟练工。

DOI:
10.1161/01.atv.21.5.722
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发表时间:
2001
期刊:
Arteriosclerosis, thrombosis, and vascular biology
影响因子:
--
通讯作者:
MillerJr,FJ
MillerJr,FJ
中科院分区:
--
文献类型:
--
作者:
MillerJr,FJ

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Although it has been 20 years since the acceptance of the endothelial layer as more than a hemostatic barrier in the blood vessel, the adventitia continues to be primarily considered a supporting structure, and its role in vascular disease has been easily dismissed. However, there is increasing support for the adventitia as a mediator of vascular dysfunction and a potential therapeutic target. 1, 2 In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Shi et al3 report elevated superoxide levels in coronary adventitial fibroblasts within 1 day of balloon injury. The source of superoxide appears to be NAD (P) H oxidase.
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