Weakening of functional corticomuscular coupling during muscle fatigue.
Weakening of functional corticomuscular coupling during muscle fatigue.
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DOI：
10.1016/j.brainres.2008.10.074
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发表时间：
2009-01-23
期刊：
影响因子：
2.9
通讯作者：
Yue GH
中科院分区：
文献类型：
--
作者：
Yang Q;Fang Y;Sun CK;Siemionow V;Ranganathan VK;Khoshknabi D;Davis MP;Walsh D;Sahgal V;Yue GH
最近的研究表明，在随意肌肉疲劳期间，大脑和肌肉信号的变化之间存在分离，这可能表明功能性皮质肌耦合减弱。然而，这种脑-肌肉耦合的减弱从未被直接评估过。这项研究的目的是通过量化肌肉经历轻微疲劳和严重疲劳时的脑电-肌电一致性来解决这个问题。9名健康受试者进行30%最大屈肘等长运动直至力竭，同时记录他们的脑(EEG)和肌肉(EMG)活动。脑电和肌电记录的整个持续时间被分为前半部分(阶段1，疲劳程度最低)和后半部分(阶段2，疲劳程度更严重)。计算各阶段的EEG-EMG相干性和功率谱。与阶段1相比，在15-35 Hz频段，阶段2的脑电和肌电的功率均显著增加，而一致性显著降低。尽管在肌肉疲劳的情况下，脑电和肌电活动的功率都有所提高，但疲劳在贝塔频率上削弱了大脑-肌肉信号耦合的强度。皮质肌偶联的减弱可能是导致肌肉疲劳和相关的运动能力障碍的主要神经机制。
Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address this issue by quantifying EEG-EMG coherence at times when muscles experienced minimal versus significant fatigue. Nine healthy subjects sustained an isometric elbow flexion at 30% maximal level until exhaustion while their brain (EEG) and muscle (EMG) activities were recorded. The entire duration of the EEG and EMG recordings was divided into the first half (stage 1 with minimal fatigue) and second half (stage 2 with severer fatigue). The EEG-EMG coherence and power spectrum in each stage was computed. The power of both EEG and EMG increased significantly while their coherence decreased significantly in stage 2 compared with stage 1 at beta (15-35 Hz) band. Despite an elevation of the power for both the EEG and EMG activities with muscle fatigue, the fatigue weakens strength of brain-muscle signal coupling at beta frequency. Weakening of corticomuscular coupling may be a major neural mechanism contributing to muscle fatigue and associated performance impairment.
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