Dietary Chitosan Supplementation Increases Microbial Diversity and Attenuates the Severity of Citrobacter rodentium Infection in Mice.
Dietary Chitosan Supplementation Increases Microbial Diversity and Attenuates the Severity of Citrobacter rodentium Infection in Mice.
复制标题
膳食中补充壳聚糖可增加小鼠微生物多样性并减轻啮齿类柠檬酸杆菌感染的严重程度
DOI：
10.1155/2016/9236196
复制
发表时间：
2016
影响因子：
4.6
通讯作者：
Fang J
中科院分区：
文献类型：
--
作者：
Guan G;Wang H;Chen S;Liu G;Xiong X;Tan B;Duraipandiyan V;Al-Dhabi NA;Fang J
为探讨壳聚糖（COS）对C57 BL/6小鼠肠道菌群及抗鼠柠檬酸杆菌感染的影响，本研究采用C57 BL/6小鼠为实验动物，研究了不同剂量COS对小鼠肠道菌群及抗鼠柠檬酸杆菌感染的影响。研究结果表明，在食用300 mg/kg COS饮食14天后，由于补充剂，微生物菌群变得更加多样化。接受COS的小鼠表现出拟杆菌门百分比的增加和厚壁菌门百分比的减少。感染枸橼酸杆菌后，组织病理学评分表明，COS喂养导致较轻的结肠炎。COS组小鼠结肠组织中IL-6和TNF-α水平显著低于对照组。COS组结肠组织核因子-κ B（NF-κB）活性明显降低。总体而言，研究结果显示，在饮食中添加300 mg/kg COS改变了小鼠肠道微生物群落的组成，导致NF-κB活化受到抑制，TNF-α和IL-6的产生减少;这些变化导致更好地控制炎症和C感染的消退。啮齿动物。
C57BL/6 mice were tested in order to investigate the effects of dietary chitosan (COS) supplements on intestinal microflora and resistance toCitrobacter rodentiuminfection. The findings reveal that, after consuming a 300 mg/kg COS diet for 14 days, microflora became more diverse as a result of the supplement. Mice receiving COS exhibited an increase in the percentage of Bacteroidetes phylum and a decrease in the percentage of Firmicutes phylum. AfterCitrobacter rodentiuminfection, the histopathology scores indicated that COS feeding resulted in less severe colitis. IL-6 and TNF-αwere significantly lower in colon from COS-feeding mice than those in the control group. Furthermore, mice in COS group were also found to experience inhibited activation of nuclear factor-kappa B (NF-κB) in the colonic tissue. Overall, the findings revealed that adding 300 mg/kg COS to the diet changed the composition of the intestinal microflora of mice, resulting in suppressed NF-κB activation and less production of TNF-αand IL-6; and these changes led to better control of inflammation and resolution of infection withC. rodentium.
登录
查看更多内容
影响因子：
64.8
作者：
Subramanian, Sathish;Huq, Sayeeda;Yatsunenko, Tanya;Haque, Rashidul;Mahfuz, Mustafa;Alam, Mohammed A.;Benezra, Amber;DeStefano, Joseph;Meier, Martin F.;Muegge, Brian D.;Barratt, Michael J.;VanArendonk, Laura G.;Zhang, Qunyuan;Province, Michael A.;Petri, William A., Jr.;Ahmed, Tahmeed;Gordon, Jeffrey I.
通讯作者：
Gordon, Jeffrey I.
小鼠膳食精氨酸补充剂改变微生物群并激活肠道先天免疫
影响因子：
4.2
作者：
Ren, Wenkai;Chen, Shuai;Wu, Guoyao
通讯作者：
Wu, Guoyao
影响因子：
2.5
作者：
Cario, Elke
通讯作者：
Cario, Elke
影响因子：
4.7
作者：
Qin, Chubin;Zhang, Yuting;Zhou, Zhigang
通讯作者：
Zhou, Zhigang
影响因子：
8
作者：
通讯作者：
--