EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid.
EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid.
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DOI：
10.1186/s40035-022-00282-5
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发表时间：
2022-02-09
影响因子：
12.6
通讯作者：
Burns JM
中科院分区：
文献类型：
--
作者：
Devos H;Gustafson K;Liao K;Ahmadnezhad P;Estes B;Martin LE;Mahnken JD;Brooks WM;Burns JM
虽然越来越多的证据表明阿尔茨海默病（AD）临床前小鼠模型中β-淀粉样蛋白（Aβ）和神经元过度兴奋有关，但人类中的类似关联尚未建立。本研究的第一个目的是确定认知正常（CN）老年人中Aβ（Aβ+）升高与P3事件相关电位（ERP）测量的认知过程之间的关联。第二个目的是比较CNAβ+和CNAβ−之间的事件相关把握度。17名CNAβ+参与者（年龄：73 ± 5，11名女性，蒙特利尔认知评估[莫卡]评分26 ± 2）和17名年龄、性别和莫卡组匹配的CNAβ-参与者在佩戴256通道脑电图网时完成工作记忆任务（n = 0，1，2）。使用线性混合模型比较两组之间的目标、非目标和任务差异效应（非目标-目标）的P3峰值振幅和潜伏期，以及从Fz、Cz和Pz中提取的δ、θ、α和β频带中的事件相关功率。Fz处任务差异效应的P3振幅和δ带中的事件相关功率被认为是主要结果。采用Pearson相关系数r分析正电子发射断层扫描Aβ标准摄取值比值（SUVR）与P3波幅和潜伏期的相关性。CNAβ+组在Fz点的P3峰幅值较低（P = 0.048）。同样，在CNAβ+参与者中，Fz处非靶点的δ波段的把握度较低（P = 0.04）。CNAβ+参与者在Cz和Pz通道中也表现出更高的theta和alpha功率，但P3 ERP没有变化。在CNAβ+组中，平均Aβ SUVR与通道Fz处任务差异效应的1-back（r =-0.69; P = 0.003）和2-back（r =-0.69; P = 0.004）潜伏期之间存在强相关性。我们的数据表明，在认知正常的老年人中，淀粉样蛋白的升高与神经元的过度兴奋有关。P3任务差异的降低可能反映了工作记忆过程的早期损伤。进一步的研究是必要的，以确定有效性的ERP预测临床，神经生物学和功能表现的AD。在线版本包含补充材料，可通过10.1186/s40035-022-00282-5获取。
Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event-related power between CNAβ+ and CNAβ−. Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, Montreal Cognitive Assessment [MoCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and MOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 amplitude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Similarly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ participants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69; P = 0.003) and 2-back (r = − 0.69; P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Our data suggest that the elevated amyloid in cognitively normal older adults is associated with neuronal hyperexcitability. The decreased P3 task difference likely reflects early impairments in working memory processes. Further research is warranted to determine the validity of ERP in predicting clinical, neurobiological, and functional manifestations of AD. The online version contains supplementary material available at 10.1186/s40035-022-00282-5.
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tau，淀粉样蛋白和级联网络失败在阿尔茨海默氏病谱系中。
DOI：
10.1016/j.cortex.2017.09.018
发表时间：
2017-12
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Jones DT;Graff-Radford J;Lowe VJ;Wiste HJ;Gunter JL;Senjem ML;Botha H;Kantarci K;Boeve BF;Knopman DS;Petersen RC;Jack CR Jr
通讯作者：
Jack CR Jr
DOI：
10.1016/0013-4694(96)00288-x
发表时间：
1996-04-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Gevins, A;Smith, ME;Whitfield, S
通讯作者：
Whitfield, S
影响因子：
25
作者：
Fu H;Hardy J;Duff KE
通讯作者：
Duff KE
影响因子：
4.7
作者：
Gevins, Alan;Smith, Michael E.;Abraham, Gordon
通讯作者：
Abraham, Gordon
影响因子：
3.7
作者：
Kappenman ES;Luck SJ
通讯作者：
Luck SJ