SCOP2 prototype: a new approach to protein structure mining.

SCOP2 prototype: a new approach to protein structure mining.
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DOI:
10.1093/nar/gkt1242
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发表时间:
2014-01
影响因子:
14.9
通讯作者:
Murzin AG
Murzin AG
中科院分区:
生物学2区
文献类型:
--
作者:
Andreeva A;Howorth D;Chothia C;Kulesha E;Murzin AG

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我们提出了一个新的蛋白质结构分类的原型,SCOP 2(http://scop2.mrc-lmb.cam.ac.uk/),我们最近开发的。SCOP 2是蛋白质结构分类(SCOP,http://scop.mrc-lmb.cam.ac.uk/scop/)数据库的后继者。与SCOP类似,SCOP 2的主要重点是根据其结构和进化关系组织结构特征蛋白质。SCOP 2旨在为蛋白质结构注释和分类提供更先进的框架。它定义了一种新的蛋白质分类方法,与SCOP有本质的不同,但保留了其最佳特征。SCOP 2分类是用有向非循环图来描述的,其中节点形成多对多关系的复杂网络,并由蛋白质结构和序列的区域表示。新的分类项目预计将确保该领域的新进展,并开辟新的研究领域。
We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural Classification of Proteins (SCOP, http://scop.mrc-lmb.cam.ac.uk/scop/) database. Similarly to SCOP, the main focus of SCOP2 is to organize structurally characterized proteins according to their structural and evolutionary relationships. SCOP2 was designed to provide a more advanced framework for protein structure annotation and classification. It defines a new approach to the classification of proteins that is essentially different from SCOP, but retains its best features. The SCOP2 classification is described in terms of a directed acyclic graph in which nodes form a complex network of many-to-many relationships and are represented by a region of protein structure and sequence. The new classification project is expected to ensure new advances in the field and open new areas of research.
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