Changing prevalence and treatment of depression among older people over two decades.
Changing prevalence and treatment of depression among older people over two decades.
复制标题
DOI：
10.1192/bjp.2019.193
复制
发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Cognitive Function and Ageing Studies Collaboration
中科院分区：
文献类型：
--
作者：
Arthur A;Savva GM;Barnes LE;Borjian-Boroojeny A;Dening T;Jagger C;Matthews FE;Robinson L;Brayne C;Cognitive Function and Ageing Studies Collaboration
抑郁症是残疾的主要原因，老年人特别容易受到不良后果的影响。调查老年人抑郁症的患病率和抗抑郁药的使用是否在二十年内发生了变化。认知功能和老龄化研究（CFAS I和CFAS II）是两项针对≥65岁老年人的英国人群队列研究，每个队列的基线测量间隔20年（1990年至1993年和2008年至2011年）。通过老年精神状态检查评估抑郁症，并使用计算机辅助分类算法的自动老年检查进行诊断。在CFAS I中，对7635名年龄≥65岁的人进行了访谈，其中1457人进行了诊断评估。在CFAS II中，对7762人进行了访谈和诊断评估。CFAS II的标准化抑郁患病率为6.8%（95%CI 6.3-7.5%），与CFAS I相比无显著性下降（风险比0.82，95%CI 0.64-1.07，P = 0.14）。在CFAS II时，10.7%的人群（95%CI 10.0-11.5%）正在服用抗抑郁药物，是CFAS I的两倍多（风险比2.79，95%CI 1.96-3.97，P < 0.0001）。在护理院居民中，抑郁症患病率没有变化，但抗抑郁药的使用从7.4%（95%CI 3.8-13.8%）增加到29.2%（95%CI 22.6-36.7%）。在20年间，≥65岁人群中报告使用抗抑郁药物的人群比例大幅增加。然而，没有证据表明特定年龄的抑郁症患病率发生了变化。
Depression is a leading cause of disability, with older people particularly susceptible to poor outcomes. To investigate whether the prevalence of depression and antidepressant use have changed across two decades in older people. The Cognitive Function and Ageing Studies (CFAS I and CFAS II) are two English population-based cohort studies of older people aged ≥65 years, with baseline measurements for each cohort conducted two decades apart (between 1990 and 1993 and between 2008 and 2011). Depression was assessed by the Geriatric Mental State examination and diagnosed with the Automated Geriatric Examination for Computer-Assisted Taxonomy algorithm. In CFAS I, 7635 people aged ≥65 years were interviewed, of whom 1457 were diagnostically assessed. In CFAS II, 7762 people were interviewed and diagnostically assessed. Age-standardised depression prevalence in CFAS II was 6.8% (95% CI 6.3–7.5%), representing a non-significant decline from CFAS I (risk ratio 0.82, 95% CI 0.64–1.07, P = 0.14). At the time of CFAS II, 10.7% of the population (95% CI 10.0–11.5%) were taking antidepressant medication, more than twice that of CFAS I (risk ratio 2.79, 95% CI 1.96–3.97, P < 0.0001). Among care home residents, depression prevalence was unchanged, but the use of antidepressants increased from 7.4% (95% CI 3.8–13.8%) to 29.2% (95% CI 22.6–36.7%). A substantial increase in the proportion of the population reporting taking antidepressant medication is seen across two decades for people aged ≥65 years. However there was no evidence for a change in age-specific prevalence of depression.
登录
查看更多内容
影响因子：
168.9
作者：
Matthews, Fiona E.;Arthur, Antony;Barnes, Linda E.;Bond, John;Jagger, Carol;Robinson, Louise;Brayne, Carol
通讯作者：
Brayne, Carol
DOI：
10.1097/nmd.0b013e3181b0c081
发表时间：
2009-08
期刊：
The Journal of nervous and mental disease
影响因子：
--
作者：
Wetherell JL;Petkus AJ;McChesney K;Stein MB;Judd PH;Rockwell E;Sewell DD;Patterson TL
通讯作者：
Patterson TL
DOI：
10.1080/00048670601050465
发表时间：
2007-01-01
影响因子：
4.6
作者：
Goldney, Robert D.;Fisher, Laura J.;Hawthorne, Graerne
通讯作者：
Hawthorne, Graerne
DOI：
10.5455/msm.2016.28.129-132
发表时间：
2016-04-01
期刊：
Materia socio-medica
影响因子：
--
作者：
Zelko, Erika;Klemenc-Ketis, Zalika;Tusek-Bunc, Ksenija
通讯作者：
Tusek-Bunc, Ksenija
影响因子：
7.8
作者：
Aarts, N.;Noordam, R.;Visser, L. E.
通讯作者：
Visser, L. E.