Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers.
Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers.
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DOI：
10.5194/aab-63-483-2020
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发表时间：
2020
影响因子：
1.8
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Hou H;Wang X;Zhang C;Tu Y;Lv W;Cai X;Xu Z;Yao J;Yang C
面部色素沉着是鸡，尤其是产蛋鸡的重要经济性状，会影响淘汰蛋鸡的胴体外观。因此，确定基因组区域并探索该区域的功能有助于了解肤色性状的变异，对育种具有重要意义。本研究选用291只纯种信阳青壳蛋鸡，其中黑脸鸡75只，白面鸡216只。采用GBS基因分型技术对人群进行测序和分型。通过全基因组关联研究（GWAS）和扫描分析获得的高质量SNP和色素沉着表型。基于这两种分析方法，我们在20号染色体上鉴定了具有68个显著SNP的相同基因组区域（10.70-11.60 Mb）（），定位到10个已知基因，包括NPEPL 1、EDN 3、GNAS、C20 orf 85、VAPB、BMP 7、TUBB 1、ELMO 2、DDX 27和NCOA 5，这些基因与皮肤色素沉着过度相关。
Facial pigmentation is an important economic trait of chickens, especially for laying hens, which will affect the carcass appearance of eliminated layers. Therefore, identifying the genomic regions and exploring the function of this region that contributes to understanding the variation of skin color traits is significant for breeding. In the study, 291 pure-line Xinyang blue-shelled laying hens were selected, of which 75 were dark-faced chickens and 216 were white-faced chickens. The population was sequenced and typed by GBS genotyping technology. The obtained high-quality SNPs and pigmentation phenotypes were analyzed by a genome-wide association study (GWAS) and a scan. Based on the two analytical methods, we identified a same genomic region (10.70–11.60 Mb) on chromosome 20 with 68 significant SNPs (), mapped to 10 known genes, including NPEPL1, EDN3, GNAS, C20orf85, VAPB, BMP7, TUBB1, ELMO2, DDX27, and NCOA5, which are associated with dermal hyperpigmentation.
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