Prevalence of Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Dataset.
Prevalence of Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Dataset.
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DOI：
10.1002/acr2.11388
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发表时间：
2022-04
影响因子：
3.4
通讯作者：
Mandl LA
中科院分区：
文献类型：
--
作者：
Lieber SB;Navarro-Millán I;Rajan M;Curtis JR;Sattui SE;Lui G;Schwartzman S;Mandl LA
虚弱与残疾和死亡率相关，与年龄无关。虽然研究已经评估了类风湿性关节炎（RA）的虚弱，但关于强直性脊柱炎（AS）和银屑病关节炎（PsA）虚弱患病率的信息有限。我们的目的是确定AS和PsA中虚弱的患病率，并评估已知与虚弱相关的特征，包括焦虑，在这三种类型的炎性关节炎中是否不同。我们对2014年入组的65岁或以上AS、PsA或RA的医疗保险和医疗补助服务中心（CMS）受益人进行了一项横断面研究。我们使用经过验证的基于声明的虚弱指数来操作虚弱。我们还探讨了年龄小于65岁的CMS受益人中工作残疾的虚弱患病率，这是一个年轻的人群，也可能有虚弱的风险。65岁及以上AS和PsA患者的虚弱患病率分别为45.2%和46.7%，显著低于RA患者的65.9%（P < 0.05）。年龄小于65岁的受益人的虚弱患病率总体上要低得多，但仍以RA最高，RA、AS和PsA分别为11.7%、4.4%和7.0%（P < 0.05）。各年龄段的受试者，尤其是65岁以下的受试者中，焦虑与虚弱有显著相关性（P < 0.05）。65岁或65岁以上的AS或PsA受益人中几乎有一半是体弱的，高于年轻的残疾受益人。需要进一步的研究来了解这些疾病中出现虚弱的风险。虚弱与焦虑有关，特别是在年轻群体中。
Frailty is associated with disability and mortality independent of age. Although studies have evaluated frailty in rheumatoid arthritis (RA), information on the prevalence of frailty in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) is limited. We aimed to determine the prevalence of frailty in AS and PsA and to evaluate whether characteristics known to be associated with frailty, including anxiety, differ among these three types of inflammatory arthritis. We performed a cross sectional study of Centers for Medicare & Medicaid Services (CMS) beneficiaries aged 65 years or older with AS, PsA, or RA enrolled in 2014. We operationalized frailty using a validated claims‐based frailty index. We also explored the prevalence of frailty among CMS beneficiaries younger than age 65 years with work disability, a younger population that also may be at risk of frailty. The prevalence of frailty in beneficiaries aged 65 years or older with AS and PsA was 45.2% and 46.7%, respectively, significantly lower than in RA (65.9%, P < 0.05). The prevalence of frailty in beneficiaries less than 65 years old was much lower overall, though still highest in RA; 11.7%, 4.4%, and 7.0% in RA, AS, and PsA, respectively (P < 0.05). Anxiety was significantly associated with frailty in subjects of all ages, particularly among those less than 65 years old (P < 0.05). Almost half of beneficiaries with AS or PsA aged 65 years old or older were frail, higher than in younger disabled beneficiaries. Further studies are needed to understand the risks of developing frailty in these diseases. Frailty was associated with anxiety, particularly in the younger age groups.
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影响因子：
2.5
作者：
Cleutjens F;van Moerbeke A;Boonen A;van Onna M
通讯作者：
van Onna M
影响因子：
3
作者：
Segal JB;Chang H-Y;Du Y;Walston JD;Carlson MC;Varadhan R
通讯作者：
Varadhan R
影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
4.7
作者：
England, Bryant R.;Sayles, Harlan;Michaud, Kaleb
通讯作者：
Michaud, Kaleb
DOI：
10.1093/gerona/61.3.262
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
通讯作者：
Fried, LP