Tuning phenols with Intra-Molecular bond Shifted HYdrogens (IM-SHY) as diaCEST MRI contrast agents.
Tuning phenols with Intra-Molecular bond Shifted HYdrogens (IM-SHY) as diaCEST MRI contrast agents.
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DOI：
10.1002/chem.201403943
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发表时间：
2014-11-24
影响因子：
4.3
通讯作者：
McMahon, Michael T.
中科院分区：
文献类型：
--
作者：
Yang, Xing;Yadav, Nirbhay N.;Song, Xiaolei;Banerjee, Sangeeta Ray;Edelman, Hannah;Minn, Il;van Zijl, Peter C. M.;Pomper, Martin G.;McMahon, Michael T.
关键词：
We characterize what the optimal exchange properties are for CEST contrast agents on 3T clinical scanners using CW saturation transfer, and demonstrate that the exchangeable protons in phenols can be tuned to reach these criteria through proper ring substitution. Systematic modification allows the chemical shift of the exchangeable protons to be positioned between 4.8 ppm to 12 ppm from water and enables adjustment of the proton exchange rate to maximize CEST contrast at these shifts. In particular, 44 hydrogen-bonded phenols are investigated for their potential as CEST MRI contrast agents and the stereoelectronic effects on their CEST properties summarized. Furthermore, we identify a pair of compounds, 2,5-dihydroxyterephthalic acid (42) and 4,6-dihydroxyisophthalic acid (43), which produce the highest sensitivity through incorporating two exchangeable protons per ring.
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影响因子：
15
作者：
Liu, Guanshu;Liang, Yajie;Bar-Shir, Amnon;Chan, Kannie W. Y.;Galpoththawela, Chulani S.;Bernard, Segun M.;Tse, Terence;Yadav, Nirbhay N.;Walczak, Piotr;McMahon, Michael T.;Bulte, Jeff W. M.;van Zijl, Peter C. M.;Gilad, Assaf A.
通讯作者：
Gilad, Assaf A.
影响因子：
2.2
作者：
BRZEZINSKI, B;ZUNDEL, G
通讯作者：
ZUNDEL, G
影响因子：
158.5
作者：
Harisinghani, MG;Barentsz, J;Weissleder, R
通讯作者：
Weissleder, R
影响因子：
15
作者：
Friedman, Joshua I.;McMahon, Michael T.;Stivers, James T.;Van Zijl, Peter C. M.
通讯作者：
Van Zijl, Peter C. M.
影响因子：
2.9
作者：
Castelli, Daniela Delli;Terreno, Enzo;Aime, Silvio
通讯作者：
Aime, Silvio