Pulmonary thrombotic microangiopathy caused by gastric carcinoma.
Pulmonary thrombotic microangiopathy caused by gastric carcinoma.
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DOI：
10.1136/jcp.2010.075739
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发表时间：
2010-04
影响因子：
3.4
通讯作者：
Nakayama T
中科院分区：
文献类型：
--
作者：
Yokomine T;Hirakawa H;Ozawa E;Shibata K;Nakayama T
肺肿瘤血栓性微血管病（PTTM）的特征是广泛扩散的肿瘤栓塞，伴纤维细胞内膜增生和小肺动脉和小动脉血栓形成。PTTM是一种罕见但致命的癌症并发症，其发病机制尚不清楚。本文报道一例胃腺癌引起的PTTM尸检病例，PTTM病变处肿瘤细胞对血小板衍生生长因子（PDGF）和PDGF受体（PDGFR）免疫反应阳性，增殖的纤维肌肉内膜细胞也表达PDGFR。此外，在肺泡巨噬细胞中检测到PGDF的过表达。这些发现表明来自肺泡巨噬细胞和肿瘤细胞的PDGF可能共同促进纤维细胞内膜增殖。据作者所知，激活的肺泡巨噬细胞可能参与PTTM之前尚未报道。
Pulmonary tumour thrombotic microangiopathy (PTTM) is characterised by wide spread tumour emboli along with fibrocellular intimal proliferation and thrombus formation in small pulmonary arteries and arterioles. PTTM is a rare but fatal complication of carcinoma, but the pathogenesis remains to be clarified. An autopsy case of PTTM caused by gastric adenocarcinoma is described, in which tumour cells in the PTTM lesion had positive immunoreactivity for platelet-derived growth factor (PDGF) and PDGF receptor (PDGFR), and proliferating fibromuscular intimal cells also showed expression of PDGFR. In addition, the overexpression of PGDF was detected in the alveolar macrophages. These findings suggest that PDGF derived from alveolar macrophages and from tumour cells may act together in promoting fibrocellular intimal proliferation. To the best of the authors' knowledge, the possible involvement of activated alveolar macrophages in PTTM has not been previously reported.
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DOI：
10.1016/s0232-1513(11)80316-6
发表时间：
1990-01-01
期刊：
EXPERIMENTAL PATHOLOGY
影响因子：
--
作者：
YOSHIDA, K;YASUI, W;TAHARA, E
通讯作者：
TAHARA, E
影响因子：
9
作者：
Katano, M;Nakamura, M;Morisaki, T
通讯作者：
Morisaki, T
影响因子：
4.8
作者：
Gelderloos, JA;Rosenkranz, S;Kazlauskas, A
通讯作者：
Kazlauskas, A
影响因子：
2.2
作者：
Chinen, K;Kazumoto, T;Tsuchiya, E
通讯作者：
Tsuchiya, E
影响因子：
6.2
作者：
VONHERBAY, A;ILLES, A;OTTO, HF
通讯作者：
OTTO, HF