Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I.
Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I.
复制标题
眼压升高引起视神经轴突运输受阻。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
Douglas R. Anderson
中科院分区：
文献类型：
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作者：
N. Sossi;Douglas R. Anderson
先前的研究表明，眼内压升高会阻断视神经筛板处的快速轴突运输。在这项研究中，IOP诱导的轴突运输的阻滞在由血管紧张素I诱导的血压升高的猫中比在正常血压的对照动物中更大。心血管因素影响IOP诱导的轴突运输阻滞的事实表明，这是由于缺血;如果阻滞是IOP对轴突的直接机械作用，则不应受BP影响。数据还表明，血管紧张素I的血管收缩特性降低了视神经乳头血管系统在受到IOP升高挑战时的自动调节能力。
Previous studies have shown that elevation of intraocular pressure blocks rapid axonal transport at the lamina cribrosa of the optic nerve. In this study, IOP-induced blockage of axonal transport was greater in cats with elevation of BP induced by angiotensin I than in control animals with normal BP. The fact that cardiovascular factors influenced IOP-induced blockage of axonal transport suggests that it is due to ischemia; if the blockage were a direct mechanical effect of the IOP on the axons, it should be unaffected by BP. The data also suggest that the vasoconstrictive properties of angiotensin I reduced the ability of the vasculature of the optic nerve head to autoregulate when challenged by elevation of IOP.
影响因子：
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作者：
QUIGLEY, HA;ADDICKS, EM;MAUMENEE, AE
通讯作者：
MAUMENEE, AE